Table 1

Baseline characteristics of the patients stratified by groups of change in albuminuria and SBP from baseline to month 6

CharacteristicsConcordant (negative) UAE <median* SBP <median**Discordant UAE <median* SBP >median**Discordant UAE >median* SBP <median**Concordant (positive) UAE >median* SBP >median**
n153112120146
Changes 0–6 months
 Median interquartile change UAE (%)35 (7–92)35 (0–85)−48 (−63 to −33)−51 (−68 to −37)
 Median interquartile change SBP (mmHg)0 (−7 to 5)−21 (−28 to −15)−5 (−9 to 5)−21 (−28 to −16)
Demographic characteristics
 Age (years)58.3 ± 8.158.7 ± 8.657.9 ± 7.557.1 ± 8.2
 Male sex, n (%)104 (68.0)82 (73.2)77 (64.2)100 (68.5)
 Race, n (%)
  White148 (96.7)110 (99.1)117 (98.3)141 (96.6)
  Nonwhite5 (3.3)1 (0.9)2 (1.7)2 (1.4)
Clinical characteristics
 BMI (km/m2)29.9 ± 4.229.9 ± 4.130.4 ± 4.230.0 ± 4.2
 Known duration of diabetes >5 years, n (%)112 (73.2)80 (71.4)82 (68.3)100 (68.5)
 Smoking, n (%)24 (15.7)22 (19.6)20 (16.7)31 (21.2)
Laboratory variables
 Glycated hemoglobin (%)7.4 ± 1.77.1 ± 1.67.1 ± 1.77.2 ± 1.7
 BP (mmHg)
  Systolic149 ± 13#158 ± 15149 ± 13#158 ± 13
  Diastolic88 ± 8$92 ± 1089 ± 8$92 ± 10
 UAE (µg/min)68.8 ± 42.556.3 ± 35.168.9 ± 41.666.1 ± 39.3
 eGFR (MDRD) (mL/min)74 ± 1471 ± 1470 ± 1372 ± 13
 Cholesterol (mg/dL)
  Total216 ± 41224 ± 43230 ± 60225 ± 43
  LDL137 ± 36141 ± 33142 ± 53140 ± 40
  HDL43 ± 1144 ± 1243 ± 1244 ± 12
  • Negative concordant indicates no robust (i.e., more than median) response in neither UAE and SBP, and positive concordant indicates no robust (i.e., more than median) response in both parameters. MDRD, Modification of Diet in Renal Disease study equation.

  • *Median UAE response was 18% decline;

  • **median SBP response was 11 mmHg decline;

  • #P < 0.001 vs. patients with UAE <median and SBP >median and patients with UAE >median and SBP >median;

  • $P < 0.05 vs. patients with UAE <median and SBP >median and patients with UAE >median and SBP >median.