Table 2

Immune cell populations

Cell populationBaselineWeek 12 (DC4)6 Months12 Months
CD3+ CD4+
 Control dendritic cells37.7 ± 0.533.9 ± 9.947.1 ± 1.948.2 ± 2.7
 Immunosuppressive dendritic cells46.3 ± 2.745.5 ± 3.740.8 ± 4.642.9 ± 3.7
CD3+ CD8+
 Control dendritic cells20.9 ± 3.421.8 ± 3.228.6 ± 3.029.7 ± 2.7
 Immunosuppressive dendritic cells23.6 ± 1.918.6 ± 2.920.4 ± 2.222.4 ± 1.8
CD4+ CD69+
 Control dendritic cells0.6 ± 0.42.4 ± 1.20.6 ± 0.30.8 ± 0.5
 Immunosuppressive dendritic cells1.7 ± 0.82.0 ±1.00.7 ±0.21.4 ± 1.0
CD8+ CD69+
 Control dendritic cells1.7 ± 1.24.2 ± 2.40.8 ± 0.21.1 ± 0.5
 Immunosuppressive dendritic cells3.4 ± 0.73.8 ± 1.60.6 ± 0.11.7 ± 0.4
CD4+ CD45RA+
 Control dendritic cells25.2 ± 2.223.9 ± 6.724.4 ± 1.623.4 ±12.3
 Immunosuppressive dendritic cells29.5 ± 3.927.2 ± 6.029.7 ± 4.629.5 ± 2.1
CD8+ CD45RA+
 Control dendritic cells12.3 ± 2.015.8 ± 0.516.7 ±2.616.9 ±1.5
 Immunosuppressive dendritic cells13.9 ± 1.715.0 ±2.813.8 ± 2.415.7 ±1.8
CD4+ CD25HIGH FOXP3+
 Control dendritic cells2.1 ± 1.22.9 ± 1.91.3 ± 0.51.8 ± 0.7
 Immunosuppressive dendritic cells1.1 ± 0.31.7 ±0.51.8 ± 0.71.9 ± 0.7
B220+ CD11c−
 Control dendritic cells3.5 ± 2.99.6 ± 5.13.2 ± 2.65.0 ± 2.1
 Immunosuppressive dendritic cells5.0 ± 2.913.9 ± 8.85.3 ± 2.71.6 ± 0.96
CD11c+ CD83+ HLA-DR+
 Control dendritic cells73.9 ± 6.762.6 ± 13.165.6 ± 10.163.6 ± 4.7
 Immunosuppressive dendritic cells71.9 ± 6.971.0 ± 5.470.2 ± 4.957.8 ± 8.0
  • Data are means ± SEM and indicate the percentage of gated cells by fluorescence-activated cell sorter. “Immunosuppressive dendritic cells” refers to antisense oligonucleotide-treated dendritic cell recipients. DC4 at week 12 indicates the measurement of the cell populations at 1 week after the last dendritic cell administration.