Table 3

Results from neurocognitive tests by history of severe hypoglycemia

Type 1 diabetesCohen d effect size (early severe hypoglycemia vs. control)
Early severe hypoglycemia (before 6 years)Late severe hypoglycemia (after 6 years)No history of severe hypoglycemia
Sample size61413
Age (years)20.7 ± 1.519.3 ± 0.618.6 ± 0.6
WISC-IV and WAIC-IV
 Full-scale IQ95.2 ± 4.3103.3 ± 2.6100.5 ± 3.7−0.74
 Verbal comprehension index93.5 ± 3.8102.1 ± 2.3102.2 ± 4.5−0.65
 Perceptual reasoning index97.8 ± 4.8103.9 ± 3.197.6 ± 3.0−0.41
 Working memory index91.5 ± 5.1102.9 ± 2.9103.0 ± 4.4−0.80
 Processing speed index103.0 ± 3.5100.9 ± 3.2100.2 ± 4.4−0.14
WMS-IV
 Auditory memory index101.7 ± 6.5107.4 ± 3.997.8 ± 5.4−0.11
 Immediate memory index100.7 ± 9.1105.2 ± 4.696.5 ± 4.2−0.09
 Delayed memory index97.0 ± 9.5103.3 ± 3.797.5 ± 5.8−0.40
CCFIT
 CCFIT IQ107.5 ± 8.1111.9 ± 4.9107.9 ± 3.8−0.66
WCST
 Perseverative error24.8 ± 5.818.6 ± 2.817.15 ± 3.61.26
 Completed categories3.2 ± 0.85.0 ± 0.35.6 ± 0.2−1.71
  • Data are mean ± SE.