Table 3

Two-year-old measurements

Metformin (n = 154)Insulin (n = 164)P value
Adjusted age (months)28.7 ± 3.629.4 ± 3.80.08
Sex: male/female (n)86/6879/850.21
Weight (kg)14.3 ± 2.114.0 ± 2.20.18
Height (cm)90.7 ± 4.991 ± 4.80.68
Leg length (cm) (height minus crown to rump)37.9 ± 3.138.1 ± 3.30.61
Head circumference (cm)49.4 ± 1.849.3 ± 1.70.52
Chest circumference (cm)52.1 ± 3.051.6 ± 3.00.12
Upper-arm circumference (cm)17.2 ± 1.516.7 ± 1.50.002
Waist circumference (cm)50.5 ± 3.550.1 ± 40.33
Hip circumference (cm)52.1 ± 4.051.6 ± 4.00.28
Waist-to-hip ratio0.97 ± 0.050.97 ± 0.050.95
Triceps skinfold thickness (mm)10.1 ± 2.09.9 ± 2.40.50
Subscapular skinfold thickness (mm)6.3 ± 1.96.0 ± 1.70.02
Biceps skinfold thickness (mm)6.0 ± 1.95.6 ± 1.70.04
DEXAN = 57N = 57
 Total fat (g)2,421 ± 1,0022,274 ± 7110.37
 Abdominal fat (g)132 ± 73131 ± 600.92
 Thigh fat (g)266 ± 96262 ± 860.83
 Arm fat (g)196 ± 104181 ± 740.36
 Abdominal-to-thigh fat ratio0.48 ± 0.10.50 ± 0.10.33
 Lean body mass (g)10,756 ± 1,28310,736 ± 1,4010.94
 Bone mineral content (g)389 ± 69390 ± 700.95
 FFM11,095 ± 1,29311,126 ± 1,4580.91
 Total fat (%)16.4 ± 4.916.9 ± 40.34
 Abdominal fat (% of fat mass)5.3 ± 1.35.6 ± 1.30.20
 Thigh fat (% of fat mass)11.3 ± 2.511.4 ± 2.50.73
 Arm fat (% of fat mass)7.82 ± 1.77.75 ± 1.60.81
BioimpedanceN = 103N = 118
 FFM (kg)11.8 ± 1.8911.4 ± 1.450.13
 Total fat (%)16.5 ± 9.0717.1 ± 6.990.58
Maternal measures at 2-year assessment
 Height (cm)163 ± 6.6162 ± 7.40.06
 Weight (kg)87.7 ± 2682.6 ± 240.07
 BMI (kg/m2)32.6 ± 8.531.4 ± 8.20.19
 Head circumference (cm)57 ± 2.256.7 ± 2.30.30
 Waist circumference (cm)102 ± 1899.4 ± 180.22
 Upper-arm circumference (cm)35.5 ± 6.534.3 ± 5.80.08
 Hip circumference (cm)114 ± 17113 ± 180.67
 Triceps skinfold thickness (mm)27.6 ± 7.128.5 ± 7.60.32
 Subscapular skinfold thickness (mm)30.1 ± 9.130.5 ± 90.75
 Biceps skinfold thickness (mm)18.5 ± 8.717.3 ± 7.20.19
 Waist-to-hip ratio0.90 ± 0.090.88 ± 0.080.10
Bioimpedance
 FFM (kg)51.3 ± 9.2148.5 ± 9.090.01
 Total fat (%)40.1 ± 7.8338.6 ± 7.350.11