Table 2

Type 2 diabetes susceptibility loci established through candidate-gene, genome-wide linkage, and GWA studies

Gene/regionGene nameChromosomal locationIdentificationReference no.
TCF7L2Transcription factor 7-like 210q25.3Linkage study33 and 39
PPARγPeroxisome proliferator–activated receptor γ3q25Candidate gene34
KCNJ11Potassium channel, inwardly rectifying subfamily J, member 1111p15.5Candidate gene34
WFS1Wolfram syndrome 1 (wolframin)4p16.1Candidate gene35
HNF1BHNF1 homeobox B17q12Candidate gene36
JAZF1Juxtaposed with another zinc finger gene 17p15GWA37
CDC123-CAMK1DCell division cycle protein 123 homolog/calcium/calmodulin-dependent protein kinase 1D10p13-p14GWA37
TSPAN8-LGR5Tetraspanin 8 and leucine-rich-repeat-containing G-protein coupled12q21GWA37
THADAThyroid adenoma-associated2p21GWA37
ADAMS9ADAM metallopeptidase with thrombospondin type 1 motif, 93p14GWA37
NOTCH2Notch homolog 2, Drosophila1p12GWA37
ADCY5Adenylate cyclase3GWA38
CDKN2A/BCyclin-dependent kinase inhibitor 2A/B9p21GWA40
CDKAL1CDK5 regulatory subunit associated protein 1-like 16p22.2GWA34 and 40
SLC30A8Solute carrier family 30, member 88q24.11GWA34 and 40
IGF2BP2Insulin-like growth factor 2 mRNA binding protein 23q28GWA34 and 40
HHEX/IDEHematopoietically expressed homeobox and insulin-degrading enzyme10q23-q25GWA34 and 40
FTOFat mass and obesity associated16q12.2GWA34
MTNR1BMelatonin receptor 1B11q21-q22GWA42
KCNQ1Potassium channel, voltage-gated, KQT-like subfamily, member 112q21GWA32
IRS1Insulin receptor substrate 12q36GWA41
GCKRGlucokinase regulator2p23GWA42
C6PC2Glucose-6-phosphatase, catalytic 22q24.3GWA42
TNFaTumor necrosis factor-α6p21.3Candidate gene45
HNF1AHepatocyte nuclear factor 1α12q24.2Candidate gene46
HNF4AHepatocyte nuclear factor 4α20q13.12Candidate gene46