Table 1

Relationship of 8-oxodG and 8-oxoGuo with all-cause and diabetes-related mortality

OutcomeUnadjusted hazard ratio (95% CI)PAge- and sex-adjusted hazard ratio (95% CI)PMultivariate-adjusted hazard ratio (95% CI)*P
All-cause mortality
 8-oxodG
  1st Quartile1.01.01.0
  2nd Quartile0.99 (0.83–1.19)0.930.88 (0.73–1.07)0.201.00 (0.78–1.28)0.98
  3rd Quartile0.95 (0.79–1.14)0.600.81 (0.67–1.97)0.030.91 (0.71–1.15)0.41
  4th Quartile1.35 (1.13–1.61)0.0011.00 (0.83–1.20)0.991.07 (0.84–1.37)0.58
  Log 8-oxodG1.30 (1.11–1.51)0.0011.12 (0.87–1.19)0.821.01 (0.82–1.25)0.91
 8-oxoGuo
  1st Quartile1.01.01.0
  2nd Quartile1.01 (0.84–1.23)0.880.89 (0.73–1.08)0.230.96 (0.74–1.23)0.73
  3rd Quartile1.37 (1.14–1.65)<0.0010.95 (0.79–1.15)0.611.04 (0.81–1.33)0.77
  4th Quartile2.05 (1.71–2.45)<0.0011.44 (1.19–1.74)<0.0011.44 (1.12–1.85)0.004
  Log 8-oxoGuo1.97 (1.70–2.28)<0.0011.40 (1.19–1.65)<0.0011.33 (1.07–1.64)0.009
Diabetes-related mortality
 8-oxodG
  1st Quartile1.01.01.0
  2nd Quartile0.99 (0.79–1.26)0.970.88 (0.69–1.11)0.281.08 (0.79–1.74)0.63
  3rd Quartile0.95 (0.75–1.20)0.680.78 (0.61–0.98)0.040.99 (0.74–1.34)0.97
  4th Quartile1.32 (1.05–1.66)0.020.98 (0.77–1.23)0.831.21 (0.89–1.65)0.22
  Log 8-oxodG1.25 (1.03–1.53)0.030.97 (0.79–1.18)0.731.10 (0.85–1.42)0.49
 8-oxoGuo
  1st Quartile1.01.01.0
  2nd Quartile0.99 (0.77–1.28)0.960.89 (0.69–1.14)0.361.03 (0.74–1.39)0.94
  3rd Quartile1.36 (1.07–1.73)0.010.92 (0.72–1.17)0.501.00 (0.73–1.36)0.99
  4th Quartile2.13 (1.69–2.69)<0.0011.50 (1.18–1.91)<0.0011.54 (1.13–2.10)0.006
  Log 8-oxoGuo2.03 (1.69–2.45)<0.0011.48 (1.21–1.82)<0.0011.40 (1.08–1.81)0.01
  • *Covariates included in the multivariate model were age, sex, smoking status, cohabitation status, physical activity, education, BMI, presence or absence of hypertension and of microalbuminuria (urinary albumin ≥15 mg/L), glycated hemoglobin, total cholesterol, triglycerides, serum creatinine, presence or absence of retinopathy and of peripheral neuropathy, and history of acute myocardial infarction and stroke.