Table 6

Drugs approved by the FDA for weight loss*

Generic name, year of approvalTrade name(s)DoseDEA schedule
Pancreatic lipase inhibitor approved by the FDA for long-term use (≥12 months)
 Orlistat, 1999Xenical120 mg 3 times daily before mealsNot scheduled
 Orlistat, 2007Alli (over the counter)60 mg 3 times daily before mealsNot scheduled
Serotinin-2C receptor agonist approved by the FDA for long-term use (12 months)
 Lorcaserin, 2012Belviq10 mg twice dailyIV
Combination of phentermine-topiramate approved by the FDA for long-term use (12 months)
 Phentermine-topiramate, 2012Qsymia3.75/23 mg
7.5/46 mg
15/92 mg
IV
Noradrenergic drugs approved for short-term use (usually <12 weeks)
 Diethylpropion, 1959Tenuate25 mg 3 times a dayIV
Tenuate Dospan75 mg every morning
 Phentermine, 1959Adipex and many others15–30 mg/dayIV
 Benzphetamine, 1960Didrex25–50 mg 3 times dailyIII
 Phendimetrazine, 1959Bontril17.5–70 mg 3 times dailyIII
Prelu-2105 mg daily
  • DEA, U.S. Drug Enforcement Administration; FDA, U.S. Food and Drug Administration.

  • * Side effect profiles can be found in the package inserts for each agent.