Table 1

Baseline characteristics of study participants

CombinedLeanObese
N (female/male)11/106/55/5
Age (years)50 ± 749 ± 751 ± 7
BMI (kg/m2)29.2 ± 7.023.6 ± 1.735.5 ± 4.9*
Waist circumference (cm)99.1 ± 17.783.3 ± 11.5111.9 ± 9.0*
Body fat (%)34 ± 928 ± 640 ± 9*
Lean body mass (kg)56 ± 1250.7 ± 11.163.5 ± 9.5*
Fasting blood glucose (mg/dL)78.3 ± 6.877 ± 979 ± 6
Fasting free fatty acids (µmol/L)439 (370–631)439 (246–522)462 (386–678)
OGIS (mL/min/m2)528 ± 92569 ± 94482 ± 67*
Adaptation index0.808 (0.511–0.924)0.615 (0.509–0.924)0.830 (0.720–0.957)
Disposition index3.09 (2.68–5.09)2.76 (2.33–3.08)4.77 (4.33–7.55)
Insulinogenic index179 (123–396)135 (94–409)219 (147–395)
hs-CRP (mg/dL)0.09 (0.05–0.29)0.05 (0.04–0.10)0.30 (0.08–0.40)*
Systolic blood pressure (mmHg)138 ± 21133 ± 23143 ± 16
Diastolic blood pressure (mmHg)85 ± 1177 ± 993 ± 6*
Gastric emptying (t1/2)#84 ± 3490 ± 3678 ± 32
Treatment adherence21/2111/1110/10
  • Mean ± SD and median (interquartile range) are given for normal and log-normal distributed data, respectively. Significant differences (

  • *P < 0.05) as determined by unpaired t test between lean and obese persons are marked in bold.

  • #Gastric emptying as measured by the 13C-octanoic acid breath test is given as half-life (t1/2) in minutes.

  • †Compliance was confirmed by tablet counting.