Table 2

Baseline demographic, clinical, and laboratory data classified by AGE levels (RFU/mg protein)

1st AGE tertile (≤89) 2nd AGE tertile (>89 to <161) 3rd AGE tertile (≥161)Total
Characteristicn = 1,235n = 1,230n = 1,240N = 3,705P for trend
Male sex, n (%)761 (61.6)776 (63.1)721 (58.1)2,258 (60.9)0.0762
Current smokers, n (%)176 (14.3)192 (15.6)196 (15.8)564 (15.2)0.2818
History of a macrovascular event, n (%)431 (34.9)410 (33.3)454 (36.6)1,295 (35.0)0.3704
Age, mean (SD), years 66.57 (6.33)67.04 (6.60)67.11 (6.90)66.92 (6.61)0.0429
BMI, mean (SD), kg/m2 7.26 (6.02)8.04 (6.57)8.40 (6.68)7.88 (6.43)<0.0001
Diabetes duration, mean (SD), years 30.15 (5.30)29.71 (5.09)30.18 (5.42)30.02 (5.26)0.8789
History of heart failure, n (%)51 (4.1)47 (3.8)71 (5.7)169 (4.6)0.0575
Moderate or vigorous activity, n (%)576 (46.6)599 (48.7)620 (50.0)1,795 (48.4)0.0947
Aspirin or other antiplatelet agent, n (%)613 (49.6)623 (50.7)583 (47.0)1,819 (49.1)0.1921
Statin or other lipid-lowering agent, n (%)578 (46.8)533 (43.3)530 (42.7)1,641 (44.3)0.0422
β-Blocker, n (%)416 (33.7)359 (29.2)347 (28.0)1,122 (30.3)0.0021
ACE inhibitor or ARB, n (%)703 (56.9)731 (59.4)763 (61.5)2,197 (59.3)0.0197
Systolic blood pressure, mean (SD), mmHg 148.29 (21.71)146.63 (21.76)147.56 (21.43)147.52 (21.61)0.4010
Diastolic blood pressure, mean (SD), mmHg 82.30 (10.72)80.92 (10.68)81.46 (11.24)81.59 (10.90)0.0560
Total cholesterol, mean (SD), mmol/L 5.03 (1.08)5.08 (1.11)5.29 (1.31)5.13 (1.17)<0.0001
HDL cholesterol, mean (SD), mmol/L 1.22 (0.32)1.23 (0.34)1.22 (0.32)1.22 (0.33)0.7024
Triglycerides, mean (SD), mmol/L 1.89 (1.12)1.93 (1.18)2.05 (1.33)1.96 (1.21)0.0010
HbA1c, mean (SD), % 7.30 (1.31)7.34 (1.36)7.59 (1.60)7.41 (1.43)<0.0001
HbA1c, mean (SD), mmol/mol 56 (14.3)57 (14.9)59 (17.5)57 (15.6)
Urinary ACR, median (IQI), mg/mmol13.50 (6.19, 39.78)14.07 (6.27, 37.26)16.16 (7.07, 46.82)15.03 (6.81, 41.37)0.4090
Glucose, mean (SD), mmol/L 8.35 (2.50)8.37 (2.52)8.65 (3.09)8.46 (2.71)0.0052
eGFR, mean (SD), mL/min/1.73 m2 73.26 (16.02)71.28 (16.42)69.97 (18.14)71.48 (16.92)<0.0001
hs-CRP, median (IQI), mg/L1.81 (0.87, 4.08)1.68 (0.82, 3.91)1.95 (0.93, 4.22)1.81 (0.87, 4.05)0.4594
hs-cTnT, median (IQI), pg/mL 5.00 (1.50, 10.00)5.00 (1.50, 12.00)6.00 (1.50, 12.00)5.00 (1.50, 11.00)0.0233
NT-proBNP, median (IQI), pg/mL 85 (34, 208)86 (33, 210)103 (40, 264)90 (35, 223)0.0105
sRAGE, median (IQI), pg/mL 1,336 (803, 2,050)1,473 (890, 2,525)1,749 (1,118, 2,895)1,512.0 (915, 2,429)<0.0001
  • For conventions, see Table 1.