Table 4

C-statistic, IDI, relative IDI, and NRI (each with their 95% CI) for new or worsening nephropathy compared with the base modela: sRAGE and AGE

Base modela C-statistic0.8279 (0.7935–0.8623)
Base + sRAGE (log scale)
 C-statistic0.8286 (0.7942–0.8630)
 IDI0.0147 (0.0101–0.0195)
 Relative IDI (%)10.1 (7.2–12.9)
 NRI–continuous0.2537 (0.0798–0.4290)
 NRI–categoricalb0.2616 (0.1782–0.3634)
Base + AGE
 C-statistic0.8281 (0.7936–0.8626)
 IDI0.0144 (0.0095–0.0206)
 Relative IDI (%)9.9 (6.9–13.3)
 NRI–continuous0.2415 (0.0607–0.4152)
 NRI–categoricalb−0.0111 (−0.0381 to 0.0086)
  • Results are derived from the random subcohort (n = 3,500).

  • aBase model includes age, sex, randomized treatment allocations, prior history of vascular disease, duration of diabetes, current smoking, systolic blood pressure, BMI, ACR, eGFR, HbA1c, glucose, triglycerides, and total and HDL cholesterol.

  • bUsing cutoff points of 1.5% and 3% 5-year risk.