Table 2

Efficacy and safety variables in patients treated with basal-bolus and premixed insulin regimens

Basal-bolus regimenPremixed reimenP value
Glycemic control
 Mean BG concentration, the first day of therapy, mg/dL173.4 ± 54210.2 ± 560.007
 Mean BG concentration, after first day of therapy, mg/dL175.1 ± 32179 ± 430.64
 BG readings 80–180 mg/dL, %55.954.30.23
Insulin therapy
 Total, units/kg/day0.5 ± 0.30.7 ± 0.30.014
 Basal insulin, units/day
  Glargine in basal-bolus group and NPH insulin in premixed group25.5 ± 15.438.8 ± 16.60.001
 Rapid insulin, units/day
  Glulisine in basal-bolus and regular insulin in premixed group19.8 ± 8.416.6 ± 7.10.63
Hypoglycemic events (BG concentration <70 mg/dL)
 BG tests per patient/day5.7 ± 0.85.6 ± 0.80.716
 Overall, patients with hypoglycemia8 (24.2)25 (64.1)0.001
  Events, n2065
  BG readings, %1.43.2
 Fasting or prebreakfast hypoglycemia1 (3.0)5 (12.8)0.134
   Events, n15
 Morning or prelunch1 (3.0)12 (30.8)0.002
   Events, n 519
 Afternoon or predinner5 (15.2)8 (20.5)0.556
   Events, n 712
 Evening, after dinner to midnight4 (12.1)8 (20.5)0.341
   Events, n 613
 Night, midnight to 6:00 a.m.1 (3.0)9 (23.1)0.014
   Events, n 116
  • Data are mean ± SD or n (%), unless otherwise indicated.