Table 2

Glucagon levels and counterregulation during the hyperinsulinemic hypoglycemic clamp test in subjects with insulin-treated type 2 diabetes

LixisenatidePlaceboP value
Glucagon level at 0 min (pmol/L)10.7 ± 1.39.8 ± 1.20.18
Glucagon level at 60 min (pmol/L)4.5 ± 0.76.0 ± 0.80.005
Glucagon level at 120 min (pmol/L)11.2 ± 1.716.1 ± 2.60.045
∆Glucagon at 3.5 mmol/L (60–120 min) (pmol/L)6.7 ± 1.610.1 ± 2.30.20
Mean glucagon at 3.5 mmol/L (60–120 min) (pmol/L)8.1 ± 1.111.4 ± 1.60.008
AUC glucagon at 3.5 mmol/L (60–120 min) (pmol/L · min)471 ± 63668 ± 910.013
Glucagon level at 180 min (pmol/L)21.7 ± 3.421.1 ± 3.00.827
∆Glucagon at 2.8 mmol/L (120–180 min) (pmol/L)10.5 ± 2.34.9 ± 2.30.042
Mean glucagon at 2.8 mmol/L (min 120–180 min) (pmol/L)19.2 ± 2.920.7 ± 2.90.63
AUC glucagon at 2.8 mmol/L (120–180 min) (pmol/L · min)988 ± 1471,116 ± 1520.36
∆Glucagon during whole clamp (60–180 min) (pmol/L)17.2 ± 3.015.0 ± 2.50.45
AUC glucagon during whole clamp (60–180 min) (pmol/L · min)1,460 ± 2081,782 ± 290.12
Glucagon level at 240 min13.8 ± 1.923.8 ± 2.3<0.001
  • Data are reported as the mean ± SEM, unless otherwise indicated. ∆, change in level.