Table 4

Mean change in SBP, DBP, and pulse rate from baseline to week 12

PlaceboSemaglutideLiraglutide
0.1 mg0.2 mg0.4 mg0.8 mg0.8 mg E1.6 mg E1.2 mg1.8 mg
SBP, mmHg
 Estimated LS mean change from baseline−3.82.4−3.8−1.8−6.2−8.4−6.2−4.9−5.7
 ETD vs. placebo (95% CI)6.1* (0.1, 12.1)−0.1 (−6.2, 6.0)2.0 (−4.0, 7.9)−2.4 (−8.6, 3.8)−4.6 (−10.7, 1.5)−2.5 (−8.5, 3.6)−1.1 (−5.8, 3.5)−2.0 (−6.4, 2.5)
 ETD vs. liraglutide 1.2 mg (95% CI)7.2 (2.7, 11.8)1.1 (−3.6, 5.8)3.1 (−1.6, 7.8)−1.3 (−6.0, 3.5)−3.5 (−8.2, 1.2)−1.3 (−5.9, 3.3)
 ETD vs. liraglutide 1.8 mg (95% CI)8.1 (3.6, 12.5)1.9 (−2.7, 6.5)3.9 (−0.5, 8.4)−0.5 (−5.1, 4.2)−2.7 (−7.3, 1.9)−0.5 (−5.0, 3.9)
DBP, mmHg
 Estimated LS mean change from baseline−1.91.90.30.40.0−1.6−1.9−1.00.1
 ETD vs. placebo (95% CI)3.8 (−0.3, 7.9)2.1 (−2.1, 6.3)2.3 (−1.9, 6.4)1.9 (−2.4, 6.2)0.2 (−4.0, 4.5)−0.1 (−4.3, 4.1)0.8 (−2.4, 4.0)1.9 (−1.2, 5.0)
 ETD vs. liraglutide 1.2 mg (95% CI)3.0 (−0.2, 6.1)1.3 (−2.0, 4.5)1.4 (−1.8, 4.6)1.1 (−2.2, 4.4)−0.6 (−3.8, 2.6)−0.9 (−4.1, 2.3)
 ETD vs. liraglutide 1.8 mg (95% CI)1.9 (−1.2, 4.9)0.2 (−3.0, 3.4)0.3 (−2.7, 3.4)−0.0 (−3.3, 3.2)−1.7 (−4.9, 1.5)−2.0 (−5.1, 1.1)
Pulse rate, bpm
 Estimated LS mean change from baseline0.40.91.22.72.64.14.24.83.3
 ETD vs. placebo (95% CI)0.6 (−4.5, 5.6)0.8 (−4.3, 6.0)2.4 (−2.6, 7.4)2.2 (−3.0, 7.5)3.7 (−1.4, 8.9)3.9 (−1.3, 9.0)4.5 (0.6, 8.3)2.9 (−0.9, 6.7)
 ETD vs. liraglutide 1.2 mg (95% CI)−3.9 (−7.8, −0.0)−3.6 (−7.6, 0.3)−2.1 (−6.0, 1.8)−2.2 (−6.2, 1.8)−0.7 (−4.7, 3.2)−0.6 (−4.5, 3.3)
 ETD vs. liraglutide 1.8 mg (95% CI)−2.4 (−6.1, 1.4)−2.1 (−5.9, 1.8)−0.6 (−4.3, 3.2)−0.7 (−4.6, 3.2)0.8 (−3.0, 4.7)0.9 (−2.8, 4.7)
  • LS mean, least squares mean. Estimates are from an ANOVA model with treatment, country, and previous treatment as fixed effects and baseline value as the covariate; CIs for treatment differences vs. placebo are based on the Dunnett method (with 6 comparisons); CIs for treatment differences vs. liraglutide are not corrected for multiple testing. All values for SBP, DBP, and pulse rate are means, safety analysis set, last observation carried forward.

  • *P < 0.05.