Table 1

A1C, weight, and cardiovascular risk markers

GLIPULINBBIP value
VariablenMean (SD)Median (IQR)nMean (SD)Median (IQR)t testWilcoxon
A1C (%)
 Visit 1527.9 (0.3)7.9 (0.6)507.9 (0.3)7.8 (0.4)0.410.51
 Visit 2527.3 (0.3)7.3 (0.6)507.4 (0.3)7.4 (0.3)0.250.22
 13 weeks467.3 (0.8)7.2 (1.2)457.1 (0.6)7.1 (0.7)0.170.33
 26 weeks457.1 (0.6)7.1 (0.8)457.2 (0.6)7.1 (0.6)0.630.77
 Change from visit 145−0.8 (0.7)−0.8 (0.9)45−0.7 (0.6)−0.8 (0.7)0.520.56
A1C (mmol/mol)
 Visit 15262.862.85062.861.7
 Visit 25256.356.35057.457.4
 13 weeks4656.355.24554.154.1
 26 weeks4554.154.14555.254.1
Weight (kg)
 Visit 152101.1 (13.7)100.0 (16.0)5099.0 (17.4)98.2 (18.7)0.450.44
 Visit 252101.3 (14.2)99.2 (16.3)5099.7 (17.8)98.6 (21.1)0.980.65
 Baseline52101.3 (14.2)99.2 (16.9)48100.1 (17.9)98.1 (21.8)0.710.57
 26 weeks4597.3 (14.1)95.7 (16.0)4599.9 (18.1)99.4 (20.3)0.460.55
 Change from baseline45−4.8 (3.3)−4.6 (4.4)44+0.7 (3.3)+1.3 (4.0)<0.001<0.001
ACR (mg/g)
 Visit 15235.3 (69.1)10.7 (19.2)4841.7 (152.7)7.8 (9.0)0.780.02
 26 weeks4534.2 (73.5)10.2 (10.4)4356.5 (197.3)8.4 (10.7)0.480.53
 Change from visit 145−1.8 (29.5)−1.8 (7.1)41+9.5 (119.3)−1.0 (6.3)0.400.75
ACR (g/μmol)
 Visit 1524.0 (7.8)1.2 (2.2)484.7 (17.3)0.9 (1.0)
 26 weeks453.9 (8.3)1.2 (1.8)436.4 (22.3)0.9 (1.2)
 Change from visit 145−0.2 (3.3)−0.2 (0.8)43+1.1 (13.5)−0.1 (0.7)
Serum creatinine (mg/dL)
 Visit 1520.9 (0.2)0.9 (0.3)500.9 (0.2)0.9 (0.4)0.360.45
 26 weeks450.9 (0.3)0.9 (0.3)450.9 (0.2)0.9 (0.3)0.740.90
 Change from visit 1450.0 (0.2)0.0 (0.2)450.0 (0.1)0.0 (0.1)0.830.67
Serum creatinine (μmol)
 Visit 15279.6 (17.7)79.6 (26.5)5079.6 (17.7)79.6 (35.4)
 26 weeks4579.6 (26.5)79.6 (26.5)4579.6 (17.7)79.6 (26.5)
 Change from visit 1450.0 (17.7)0.0 (17.7)450.0 (8.8)0.0 (8.8)
ALT (units/L)
 Visit 15237.6 (22.8)34.0 (20.0)5032.4 (14.6)29.5 (16.0)0.180.21
 26 weeks4528.6 (13.2)26.0 (17.0)4533.4 (17.2)32.0 (15.0)0.140.17
 Change from visit 145−10.7 (16.8)−8.0 (13.0)45+0.9 (10.0)−1.0 (12.0)0.00020.0001
ALT (µkat/L)
 Visit 1520.63 (0.38)0.57 (0.33)500.54 (0.24)0.49 (0.27)
 26 weeks450.48 (0.22)0.43 (0.28)450.56 (0.29)0.53 (0.25)
 Change from visit 145−0.18 (0.28)−0.13 (0.22)450.02 (0.17)−0.02 (0.20)
SAA (mg/L)
 Baseline526.1 (6.5)4.0 (4.5)496.7 (8.8)4.6 (4.2)0.710.74
 26 weeks459.5 (29.8)3.6 (3.7)4410.8 (29.8)5.7 (4.6)0.840.01
 Change from baseline45+3.5 (30.2)−0.4 (2.3)44+5.1 (29.6)0.0 (2.3)0.800.02
CRP (mg/dL)
 Baseline520.35 (0.46)0.22 (0.30)490.44 (0.63)0.22 (0.44)0.370.99
 26 weeks450.38 (0.68)0.20 (0.17)450.38 (0.60)0.19 (0.34)0.980.68
 Change from baseline45+0.03 (0.74)−0.02 (0.21)45+0.02 (0.55)0.00 (0.13)0.950.97
Interleukin 6 (pg/mL)
 Baseline522.87 (1.57)2.60 (1.32)482.72 (1.33)2.53 (1.50)0.600.56
 26 weeks453.39 (2.08)2.74 (1.41)452.94 (1.30)2.70 (2.14)0.220.55
 Change from baseline45+0.56 (2.36)+0.11 (1.80)45+0.30 (1.00)+0.11 (0.95)0.500.76
8-iso-PGF (ng/mg)
 Baseline523,360 (3,277)1,489 (5,648)493,633 (3,716)1,849 (5,581)0.700.48
 26 weeks453,967 (4,197)1,625 (5,642)432,583 (3,011)1,113 (3,129)0.080.16
 Change from baseline45+654 (5,380)+389 (7,474)43−1,400 (4,320)−1,076 (4,503)0.0520.06
  • ACR, albumin-to-creatinine ratio; PGF, prostaglandin F.