Table 2

Baseline characteristics of the ACCORDION Eye Study participants

ACCORDION EyeGlycemiaLipidBP
Overall (N = 1,310)Intensive (n = 658)Standard (n = 652)P valueFibrate plus simvastatin (n = 399)Placebo plus simvastatin (n = 363)P valueIntensive (n = 280)Standard (n = 268)P value
Age (years)61.3 ± 5.861.4 ± 5.961.2 ± 5.70.5161.8 ± 5.861.1 ± 5.60.1461.3 ± 5.861.1 ± 6.10.63
Diabetes duration (years)9.9 ± 6.89.6 ± 6.710.1 ± 6.90.189.8 ± 6.59.4 ± 6.60.3710.5 ± 6.810.1 ± 7.30.59
Female sex493 (37.6)240 (36.5)253 (38.8)0.38110 (27.6)134 (36.9)0.006127 (45.4)122 (45.5)0.97
Previous cardiovascular event361 (27.6)187 (28.4)174 (26.7)0.48108 (27.1)100 (27.5)0.8878 (27.9)75 (28.0)0.97
Nonwhite race345 (26.3)165 (25.1)180 (27.6)0.30105 (26.3)96 (26.4)0.9769 (24.6)75 (28.0)0.37
Glycated hemoglobin (%) (mmol/mol)8.2 ± 1.0 (66 ± 10.9)8.1 ± 0.9 (65 ± 9.8)8.2 ± 1.0 (66 ± 10.9)0.088.2 ± 1.0 (66 ± 10.9)8.1 ± 0.9 (65 ± 9.8)0.178.3 ± 1.0 (67 ± 10.9)8.2 ± 1.0 (66 ± 10.9)0.35
HDL cholesterol (mg/dL)41.7 ± 10.641.9 ± 11.041.4 ± 10.30.4438.2 ± 7.438.9 ± 7.60.2446.2 ± 12.545.9 ± 12.80.72
LDL cholesterol (mg/dL)99.2 ± 32.797.7 ± 32.7100.7 ± 32.60.1094.9 ± 30.496.4 ± 29.80.49106.1 ± 36.4102.1 ± 34.40.19
Triglycerides (mg/dL)190.6 ± 152.3197.3 ± 175.0183.8 ± 125.10.11186.5 ±101.4182.8 ± 104.70.61199.1 ± 167.2198.5 ± 232.70.97
Systolic BP (mmHg)133.1 ± 16.4132.7 ± 16.1133.4 ± 16.70.47129.9 ± 15.6129.4 ± 16.80.66136.8 ± 15.9138.6 ± 15.00.17
Diastolic BP (mmHg)74.7 ± 10.474.7 ± 10.174.7 ± 10.60.9873.6 ± 10.073.2 ± 10.50.5475.4 ± 10.377.4 ± 10.20.02
Urinary albumin-to-creatinine ratio48.7 ± 164.144.9 ± 133.552.5 ± 190.10.4144.5 ± 126.258.7 ± 229.00.2843.9 ± 133.746.3 ± 134.60.84
BMI (kg/m2)32.3 ± 5.432.4 ± 5.232.3 ± 5.60.8132.0 ± 5.432.6 ± 5.30.1732.3 ± 5.632.4 ± 5.30.83
Visual acuity76.8 ± 9.776.7 ± 9.776.9 ± 9.60.7576.8 ± 9.877.2 ± 9.60.5676.9 ± 9.276.1 ± 10.00.33
Smoking status0.830.420.98
 Never smoked573 (43.8)284 (43.2)289 (44.4)164 (41.2)166 (45.7)123 (43.9)120 (44.8)
 Previous smoker588 (44.9)301 (45.7)287 (44.1)183 (46.0)157 (43.3)128 (45.7)120 (44.8)
 Current smoker148 (11.3)73 (11.1)75 (11.5)51 (12.8)40 (11.0)29 (10.4)28 (10.4)
Diabetic retinopathy status0.350.320.44
 None687 (52.4)350 (53.2)337 (51.7)219 (54.9)191 (52.6)143 (51.1)134 (50.0)
 Mild251 (19.2)119 (18.1)132 (20.2)75 (18.8)73 (20.1)51 (18.2)52 (19.4)
 Moderate NPDR362 (27.6)186 (28.3)176 (27.0)103 (25.8)98 (27.0)81 (28.9)80 (29.9)
 Severe NPDR3 (0.2)1 (0.2)2 (0.3)1 (0.3)0 (0.0)1 (0.4)1 (0.4)
 PDR7 (0.5)2 (0.3)5 (0.8)1 (0.3)1 (0.3)4 (1.4)1 (0.4)
  • NPDR, nonproliferative diabetic retinopathy; PDR, proliferative diabetic retinopathy.