Table 2

Data from inpatient CL admissions

CL aloneCL + adjunctive therapyP value
Pramlintide
 Time to peak plasma glucose (h)
  Average of all meals1.6 ± 0.52.9 ± 0.9<0.0001
  Breakfast1.5 ± 0.43.2 ± 0.6<0.0001
  Lunch1.8 ± 0.82.7 ± 1.30.01
  Dinner1.7 ± 0.32.8 ± 0.50.002
 Plasma glucose excursion (mg/dL)
  Average all meals96 ± 3059 ± 46<0.0001
  Breakfast116 ± 3091 ± 440.03
  Lunch99 ± 1942 ± 380.01
  Dinner72 ± 2343 ± 420.11
 Plasma glucose AUC meal excursion (mg/dL · h)
  Total all meals677 ± 96412 ± 1590.002
  Breakfast269 ± 117203 ± 1130.06
  Lunch239 ± 12177 ± 1030.01
  Dinner168 ± 87110 ± 1170.25
 Prandial insulin delivery (units)
  Total all meals32.6 ± 6.528.2 ± 8.80.047
  Breakfast10.7 ± 4.49.8 ± 4.40.37
  Lunch10.9 ± 2.08.4 ± 3.50.04
  Dinner12.5 ± 4.29.1 ± 2.40.04
Liraglutide
 Time to peak plasma glucose (h)
  Average all meals1.8 ± 0.51.8 ± 0.60.97
  Breakfast1.9 ± 0.52.1 ± 1.10.75
  Lunch1.4 ± 0.61.5 ± 0.90.99
  Dinner2.2 ± 0.91.7 ± 0.80.27
 Plasma glucose excursion (mg/dL)
  Average all meals98 ± 2476 ± 170.05
  Breakfast114 ± 45103 ± 560.60
  Lunch77 ± 5357 ± 210.17
  Dinner106 ± 4171 ± 430.11
 Plasma glucose AUC meal excursion (mg/dL · h)
  Total all meals789 ± 176500 ± 1510.002
  Breakfast289 ± 151226 ± 1920.27
  Lunch178 ± 178106 ± 700.32
  Dinner304 ± 143175 ± 1530.05
 Prandial insulin delivery (units)
  Total all meals22.6 ± 8.416.3 ± 8.30.005
  Breakfast8.8 ± 4.16.5 ± 4.10.006
  Lunch6.4 ± 3.05.3 ± 2.80.17
  Dinner8.2 ± 2.85.1 ± 2.10.003
  • Data are mean ± SD. System target glucose was 120 mg/dL for the pramlintide study and 100 mg/dL for the liraglutide study.