Table 5

The effects of medical therapies in ACCORD and ACCORDION on visual acuity: The results of the proportional hazard modeling for moderate visual lossa

TreatmentOriginal ACCORDACCORDIONb
n/N (%)Adjusted HR (95% CI)P valuen/N (%)Adjusted HR (95% CI)P value
Glycemia therapy0.88 (0.77–1.01)0.060.98 (0.90–1.07)0.67
    Intensive409/1,715 (23.8)508/1,715 (29.6)
    Standard457/1,737 (26.3)551/1,737 (31.7)
Dyslipidemia therapy0.95 (0.79–1.14)0.570.95 (0.84–1.08)0.45
Simvastatin and fenofibrate227/956 (23.7)284/956 (29.7)
Simvastatin and placebo233/950 (24.5)287/950 (30.2)
Antihypertensive therapy1.17 (0.96–1.42)0.121.15 (1.01–1.31)0.04
    Intensive221/798 (27.7)262/798 (32.8)
    Standard185/748 (24.7)226/748 (30.2)
  • aModerate vision loss: three or more lines of visual loss compared with baseline.

  • bParticipants who were examined in ACCORDION and had visual acuity assessments at their study/medical center.