The effects of medical therapies on the progression of diabetic retinopathy in the ACCORD and ACCORDION Studiesa
| ACCORDb | ACCORD (photographic grading data only)c | ACCORDIONd | |||||||
|---|---|---|---|---|---|---|---|---|---|
| n/N (%) | Adjusted OR (95% CI) | P value | n/N (%) | Adjusted OR (95% CI) | P value | n/N (%) | Adjusted OR (95% CI) | P value | |
| Glycemia therapy | 0.67 (0.51–0.87) | 0.003 | 0.61 (0.46–0.82) | 0.001 | 0.42 (0.28–0.63) | <0.0001 | |||
| Intensive | 104/1,429 (7.3) | 81/1,418 (5.7) | 38/658 (5.8) | ||||||
| Standard | 149/1,427 (10.4) | 126/1,418 (8.9) | 83/652 (12.7) | ||||||
| Dyslipidemia therapy | 0.60 (0.42–0.87) | 0.006 | 0.54 (0.36–0.80) | 0.002 | 1.13 (0.71–1.79) | 0.60 | |||
| Simvastatin/fenofibrate | 52/806 (6.5) | 41/802 (5.1) | 47/399 (11.8) | ||||||
| Simvastatin/placebo | 80/787 (10.2) | 70/781 (9.0) | 37/363 (10.2) | ||||||
| Antihypertensive therapy | 1.23 (0.84–1.79) | 0.29 | 0.97 (0.64–1.47) | 0.88 | 1.21 (0.61–2.40) | 0.59 | |||
| Intensive | 67/647 (10.4) | 48/640 (7.5) | 21/280 (7.5) | ||||||
| Standard | 54/616 (8.8) | 48/613 (7.8) | 16/268 (6.0) | ||||||
↵aResults of likelihood-ratio tests from logistic regression models.
↵bPreviously reported composite outcome: progression of 3 or more steps on the ETDRS severity scale of diabetic retinopathy, vitrectomy, or photocoagulation for the treatment of proliferative diabetic retinopathy.
↵cOutcome consists only of the progression of 3 or more steps on the ETDRS scale for the classification of diabetic retinopathy.
↵dAt 8 years, photographic grading data only.