Table 1

Efficacy and safety outcomes (N = 29 participants*)

Overall (day and night)Night only (2300–0700 h)Day only (0700–2300 h)
BaselineOvernight-only CLC24/7 CLCBaselineOvernight-only CLC24/7 CLCBaselineOvernight-only CLC24/7 CLC
Total sensor hours, median*335336336115113112217219218
Time spent <70 mg/dL, %, median (IQR)4.1 (2.0, 7.8)2.6 (1.6, 3.6)1.7 (1.1, 2.7)3.0 (1.1, 6.3)1.1 (0.2, 1.6)0.4 (0.2, 1.7)4.6 (2.0, 7.0)3.2 (2.1, 4.6)2.3 (1.3, 3.0)
 P vs. baselineNA0.002<0.001NA<0.001<0.001NA0.10<0.001
 P vs. night CLCNANA<0.001NANA0.31NANA<0.001
Time in range 70–180 mg/dL, %, median (IQR)65 (59, 69)73 (65, 78)73 (68, 76)61 (53, 73)75 (69, 80)72 (65, 80)65 (61, 71)70 (65, 77)72 (69, 78)
 P vs. baselineNA<0.001<0.001NA<0.001<0.001NA0.001<0.001
 P vs. night CLCNANA0.91NANA0.20NANA0.49
Sensor glucose, mg/dL, mean ± SD157 ± 18149 ± 12153 ± 12163 ± 23150 ± 12154 ± 13154 ± 19148 ± 15152 ± 14
 P vs. baselineNA0.0090.14NA0.0020.03NA0.070.54
 P vs. night CLCNANA0.06NANA0.18NANA0.07
Glucose coefficient of variation, %, median (IQR)38 (34, 41)35 (33, 37)34 (31, 37)36 (32, 40)30 (29, 34)32 (27, 36)38 (34, 42)37 (34, 39)35 (31, 37)
 P vs. baselineNA0.005<0.001NA<0.001<0.001NA0.13<0.001
 P vs. night CLCNANA0.02NANA0.52NANA<0.001
SD, mg/dL, median (IQR)61 (53, 69)52 (48, 58)51 (47, 55)61 (50, 69)47 (42, 51)48 (40, 58)58 (53, 65)55 (49, 60)53 (47, 54)
 P vs. baselineNA<0.001<0.001NA<0.001<0.001NA0.02<0.001
 P vs. night CLCNANA0.41NANA0.12NANA0.06
Time spent >180 mg/dL, %, median (IQR)32 (25, 36)24 (20, 31)25 (22, 28)37 (24, 45)24 (19, 28)27 (19, 34)31 (23, 35)23 (19, 32)25 (21, 29)
 P vs. baselineNA<0.0010.001NA<0.001<0.001NA0.020.02
 P vs. night CLCNANA0.26NANA0.11NANA0.61
  • NA, not applicable.

  • *One participant was excluded due to missing baseline CGM data.

  • †Post hoc comparison of overnight-only CLC vs. 24/7 CLC.