Table 1

DCCT/EDIC deaths and death rates by DCCT intensive versus conventional therapy group, primary versus secondary cohort, and sex, with SMRs relative to the U.S. population, along with RMRs comparing two SMRs

Observed/expected*Rate (95% CI)SMR (95% CI)RMR (95% CI)§P
Total (n = 1,441)125/114320 (269, 380)1.09 (0.92, 1.30)
Intensive (n = 711)51/58263 (200, 345)0.88 (0.67, 1.16)1.49 (1.04, 2.14)0.028
Conventional (n = 730)74/56376 (301, 470)1.31 (1.05, 1.65)
Primary (n = 726)61/54315 (247, 404)1.13 (0.88, 1.45)0.95 (0.67, 1.35)0.76
Secondary (n = 715)64/60324 (255, 412)1.07 (0.83, 1.36)
Females (n = 680)47/39252 (190, 333)1.19 (0.90, 1.59)0.87 (0.61, 1.26)0.464
Males (n = 761)78/75382 (307, 475)1.04 (0.83, 1.30)
Treatment group by sexConventional vs. Intensive
 Females
  Intensive21/21220 (145, 335)0.99 (0.64, 1.51)1.46 (0.82, 2.59)0.201
  Conventional26/18284 (195, 415)1.44 (0.98, 2.11)
 Males
  Intensive30/37304 (213, 434)0.82 (0.57, 1.18)1.54 (0.97, 2.43)0.066
  Conventional48/38456 (346, 600)1.26 (0.95, 1.66)
Treatment group by study cohortConventional vs. Intensive
 Primary
  Intensive27/26291 (200,422)1.03 (0.70, 1.51)1.17 (0.71, 1.95)0.538
  Conventional34/28338 (244,470)1.21 (0.87, 1.69)
 Secondary
  Intensive24/32237 (160,353)0.75 (0.50, 1.13)1.88 (1.13, 3.12)0.015
  Conventional40/28415 (307,562)1.42 (1.04, 1.93)
  • *Number of deaths.

  • †Rate per 100,000 PY with 95% CI from a Poisson regression model with robust information sandwich standard errors.

  • ‡Expected number of deaths from the 2013 U.S. population life table for every year of age in the cohort and the SMR.

  • §RMR obtained from an unadjusted Poisson model, each with 95% CI and P value (two sided).