Table 1

Adjusted hazard ratios (95% CI)* of peripheral vascular disease, chronic kidney disease, cardiovascular disease, and all-cause mortality according to categories of HbA1c and fasting glucose at baseline in blacks and whites without diagnosed diabetes, the ARIC Study (1990–1992), N = 11,018

HbA1c <5.0%HbA1c 5.0–5.6%HbA1c 5.7–6.5%HbA1c ≥6.5%
Peripheral vascular disease, n = 279 events
 White1.25 (0.70–2.23)1 (ref)1.63 (1.20–2.22)3.22 (1.93–5.38)
 Black2.06 (0.74–5.69)1 (ref)1.24 (0.66–2.33)2.73 (1.24–6.02)
Chronic kidney disease, n = 1,550 events
 White0.97 (0.76–1.22)1 (ref)1.30 (1.13–1.49)1.84 (1.41–2.42)
 Black2.15 (1.40–3.30)1 (ref)1.56 (1.22–2.01)1.82 (1.28–2.60)
Cardiovascular disease, n = 2,205 events
 White0.99 (0.81–1.20)1 (ref)1.51 (1.35–1.69)1.94 (1.55–2.44)
 Black0.78 (0.47–1.29)1 (ref)1.36 (1.09–1.70)2.28 (1.68–3.08)
All-cause mortality, n = 2,999 deaths
 White1.19 (1.01–1.40)1 (ref)1.37 (1.24–1.50)1.72 (1.39–2.12)
 Black1.41 (1.03–1.93)1 (ref)1.14 (0.96–1.36)1.36 (1.05–1.78)
Fasting glucose <90 mg/dLFasting glucose 90–99 mg/dLFasting glucose 100–125 mg/dLFasting glucose ≥126 mg/dL
Peripheral vascular disease, n = 279 events
 White0.79 (0.42–1.51)1 (ref)0.99 (0.72–1.35)1.26 (0.74–2.17)
 Black0.71 (0.21–2.45)1 (ref)0.68 (0.37–1.25)1.55 (0.72–3.33)
Chronic kidney disease, n = 1,550 events
 White1.07 (0.84–1.36)1 (ref)1.04 (0.91–1.18)1.25 (0.98–1.59)
 Black1.14 (0.71–1.84)1 (ref)1.16 (0.90–1.50)1.61 (1.14–2.27)
Cardiovascular disease, n = 2,205 events
 White1.27 (1.04–1.55)1 (ref)1.12 (1.00–1.25)1.40 (1.15–1.71)
 Black0.88 (0.57–1.35)1 (ref)0.89 (0.71–1.11)1.38 (1.01–1.87)
All-cause mortality, n = 2,999 deaths
 White1.01 (0.85–1.21)1 (ref)1.10 (1.00–1.21)1.54 (1.29–1.83)
 Black1.17 (0.87–1.59)1 (ref)0.89 (0.75–1.07)1.06 (0.81–1.38)
  • * Adjusted for age, sex, LDL cholesterol, HDL cholesterol, log-transformed triglycerides, BMI, waist-to-hip ratio, hypertension, family history of diabetes, education, drinking status, cigarette smoking status, and physical activity index.