Table 3

Longitudinal associations of treatment group and HbA1c level with traditional cardiovascular risk factors during the DCCT/EDIC study, fully adjusted for all other factors

Traditional cardiovascular risk factors
BMISystolicBP(mmHg)DiastolicBP(mmHg)Pulse pressure(mmHg)Pulse rate(bpm)Triglycerides (mg/dL)*HDL cholesterol(mg/dL)LDL cholesterol(mg/dL)
Men(kg/m2)Women (kg/m2)
Intensive vs. conventional−0.17 ± 0.141.01 ± 0.17−0.46 ± 0.300.34 ± 0.19−0.50 ± 0.29−1.33 ± 0.510.03 ± 1.690.82 ± 0.501.80 ± 1.03
0.2190<0.00010.12270.07290.08720.01000.98730.09970.0820
(−1.23)(5.93)(−1.54)(1.79)(−1.71)(−2.58)(0.02)(1.65)(1.74)
Current HbA1c level (%)−0.35 ± 0.02−0.25 ± 0.02−0.37 ± 0.060.22 ± 0.04−0.39 ± 0.060.33 ± 0.065.49 ± 0.230.02 ± 0.052.99 ± 0.14
<0.0001<0.0001<0.0001<0.0001<0.0001<0.0001<0.00010.6538<0.0001
(−21.61)(−14.43)(−6.49)(5.32)(−6.62)(5.89)(24.77)(0.45)(21.04)
  • Each column represents a single generalized linear mixed model jointly adjusted for all other baseline and time-dependent predictors listed in Supplementary Table 2. Data are reported as β-estimates ± SE and P values (t statistics). β-Estimates are equal to the mean difference between groups or the slope of the association. The signed t statistic corresponds to the magnitude and directionality of the association. BP, blood pressure.

  • *Triglyceride values were log transformed and the percentage change in triglycerides per 1-unit change in predictor is shown [100(eβ − 1)] ± [100(eβ*SE)].

  • †Each predictor is entered into the model as a time-dependent covariate.