Table 2

Genetic effect of CYP2C8 and SLCO1B1 variants on HbA1c reduction and weight gain (additive genetic model)

TreatmentGeneWeight gainHbA1c reduction
β95% CIPβ95% CIP
Rosiglitazone (n = 444)CYP2C8*3−0.93−1.73, −0.130.02−0.21−0.38, −0.040.01
SLCO1B1−0.13−0.92, 0.670.750.180.01, 0.340.04
Pioglitazone (n = 239)CYP2C8*3−0.46−1.45, 0.510.340.14−0.10, 0.380.26
SLCO1B1−0.02−0.92, 0.870.96−0.10−0.32, 0.120.37