Table 3

Stratified analyses according to OCT1 and SERT genotypes

OR (95% CI)P
Effect of two deficient OCT1 alleles—analysis stratified for SERT genotype
 SERT genotype
  L*L* carriers*9.25 (3.18–27.0)<0.0001
  L*S* carriers2.11 (0.99–4.50)0.054
  S*S* carriers0.45 (0.09–2.20)0.325
Effect of the number of SERT S* alleles—analysis stratified for OCT1 genotype
 OCT1 genotype
  0 or 1 deficient alleles carriers§1.48 (1.15–1.92)0.003
  2 deficient alleles carriers0.33 (0.13–0.82)0.017
  • Analyses were adjusted for age, sex, weight, and use of OCT1-inhibiting medications.

  • *Thirty-four intolerant patients and 382 tolerant patients.

  • †Eighty-one intolerant patients and 656 tolerant patients.

  • ‡Forty-nine intolerant patients and 318 tolerant patients.

  • §One hundred forty-one intolerant patients and 1,265 tolerant patients.

  • ‖Twenty-three intolerant patients and 91 tolerant patients.