Table 3

Multivariate Cox regression analysis to show HRs of calendar year of assessment with major clinical outcomes

AMIStrokeESRDAll-cause death
HR (95% CI)*P valueHR (95% CI)*P valueHR (95% CI)*P valueHR (95% CI)*P value
Model 10.971 (0.960–0.984)<0.0010.929 (0.921–0.936)<0.0010.941 (0.935–0.948)<0.0010.953 (0.947–0.958)<0.001
Model 20.975 (0.959–0.991)0.0020.920 (0.910–0.930)<0.0010.925 (0.916–0.934)<0.0010.953 (0.947–0.960)<0.001
Model 30.985 (0.969–1.002)0.0770.926 (0.916–0.935)<0.0010.955 (0.946–0.964)<0.0010.960 (0.953–0.967)<0.001
Model 40.987 (0.971–1.003)0.1100.926 (0.917–0.936)<0.0010.957 (0.948–0.966)<0.0010.963 (0.956–0.970)<0.001
  • Model 1: adjusted for age, sex, duration of diabetes; model 2: adjusted for age, sex, duration of diabetes, and interaction term year of enrollment × duration of diabetes; model 3: adjusted for age, sex, duration of diabetes, HbA1c, systolic blood pressure, LDL cholesterol, and BMI; and model 4: adjusted for age, sex, duration of diabetes, HbA1c, systolic blood pressure, LDL cholesterol, BMI, history of coronary heart disease, stroke, and ESRD.

  • *HR for outcome per calendar year of assessment from the previous calendar year.