Table 1

Clinical features of the study population according to the TCF7L2 rs7903146 genotype

CaucasiansAfrican AmericansHispanics
CCCTTTP valueCCCTTTP valueCCCTTTP value
N174187421401072414111921
Age (years)14.2 ± 3.913.6 ± 3.313.2 ± 2.90.11813.3 ± 3.413.3 ± 3.214.3 ± 4.30.36712.3 ± 3.113.1 ± 3.111.8 ± 3.10.186
Sex (male/female), %32/6844/5543/570.04142/5838/6238/620.80048/5239/6162/380.085
BMI z score2.0 ± 0.812.2 ± 0.582.1 ± 0.640.0552.3 ± 0.512.2 ± 0.712.1 ± 0.550.2972.1 ± 0.762.2 ± 0.651.9 ± 1.40.374
Tanner 1/2–3/4–5, %7/25/685/37/5812/26/620.06113/36/517/43/504/33/630.30811/45/448/38/5414/48/380.429
Fasting glucose (mg/dL)90.2 ± 8.391.2 ± 8.393.9 ± 10.30.03691.5 ± 8.692.1 ± 8.693.3 ± 7.10.46691.6 ± 7.792.7 ± 8.696.6 ± 12.00.082
2-h glucose (mg/dL)118.4 ± 26.3123.2 ± 27.4137.1 ± 34.90.006117.7 ± 28.5129.5 ± 31.5122.0 ± 26.40.009117.8 ± 20.7124.3 ± 24.4129.0 ± 31.00.072
HbA1c (%)5.4 ± 0.305.4 ± 0.305.5 ± 0.340.0575.5 ± 0.355.6 ± 0.375.7 ± 0.450.0945.5 ± 0.275.5 ± 0.365.5 ± 0.370.990
HbA1c (mmol/mol)36 ± 2.336 ± 2.337 ± 2.390.05737 ± 2.438 ± 2.439 ± 2.90.09437 ± 1.9837 ± 2.337 ± 2.40.990
Insulin (μU/mL)30.3 ± 17.234.2 ± 19.733.2 ± 15.80.22534.5 ± 18.237.4 ± 29.434.4 ± 13.70.32030.3 ± 17.235.7 ± 18.042.7 ± 32.00.038
WBISI (I2/mg/μU)2.1 ± 1.31.9 ± 1.11.8 ± 1.20.2671.8 ± 1.22.0 ± 1.61.6 ± 0.610.3222.0 ± 1.11.6 ± 0.942.1 ± 1.70.062
IGI (μU/mg)4.2 ± 4.04.2 ± 3.33.8 ± 3.40.7696.2 ± 4.86.6 ± 9.76.4 ± 5.00.0724.6 ± 3.84.6 ± 3.03.7 ± 3.50.266
DI (I2/mg2)6.9 ± 6.86.0 ± 4.35.5 ± 3.00.0909.2 ± 5.77.9 ± 7.88.6 ± 6.00.0107.6 ± 5.96.6 ± 4.76.0 ± 5.90.051
OMM
 N138127258971161107315
 Φb (10−9 min−1)14.7 ± 6.314.9 ± 6.113.3 ± 7.20.49013.8 ± 5.512.6 ± 6.712.2 ± 5.50.34713.7 ± 4.515.7 ± 6.512.1 ± 6.00.839
 Φd (10−9 min−1)1,395.9 ± 765.61,431.5 ± 929.71,386.7 ± 996.20.8801,963.7 ± 1,064.01,788.8 ± 1,270.11,431.6 ± 926.50.1271,649.0 ± 1,007.91,679.4 ± 907.91,209.2 ± 525.60.626
 Φs (10−9 min−1)81.6 ± 49.876.4 ± 43.052.2 ± 23.00.01087.4 ± 63.262.0 ± 36.375.1 ± 33.20.03985.7 ± 62.778.2 ± 34.350.8 ± 19.80.858
 Φtotal (10−9 min−1)96.4 ± 55.097.1 ± 54.764.2 ± 27.80.003111.347 ± 66.280.2 ± 40.888.1 ± 44.00.002106.8 ± 70.992.8 ± 42.566.8 ± 26.20.035
 SI (10−5 dL · kg −1 · min−1/pmol · L−1)26.1 ± 23.425.0 ± 20.230.6 ± 27.70.84124.9 ± 18.426.9 ± 21.820.4 ± 15.10.74227.1 ± 18.517.0 ± 12.124.3 ± 15.00.003
  • Data are mean ± SD unless otherwise indicated.

  • IGI, insulinogenic index; WBISI, whole-body insulin sensitivity index.