Table 3

Cause-specific HRs from a multivariate proportional hazards model for first-appearing IAA only and GADA only and multiple IA at seroconversion by age 6 years

FactorComparisonIAA onlyGADA onlyMultiple IA
SexMale vs. female1.360.
Family historyFDR mother vs. GP0.870.661.560.151.420.32
FDR father vs. GP2.33<0.00012.49<0.00012.160.02
FDR sibling vs. GP5.32<0.00011.600.332.730.05
HLADR3/4 vs. DR4/4,X1.18*0.231.92*0.00011.520.06
DR3/3,X vs. DR4/4,X0.27*<0.00011.60*
CountryFinland vs. U.S.1.93*0.00030.73*0.141.310.37
Germany vs. U.S.1.70*0.050.53*0.092.590.008
Sweden vs. U.S.1.320.120.910.571.030.91
Probiotics at age 28 daysYes vs. no or ≥28 days0.540.030.640.210.890.75
Weight at age 12 monthsz score1.
Child conditions before first clinical visit (age 3 months)Upper resp. (yes vs. no)
Lower resp. (yes vs. no)0.970.871.100.640.440.07
Diarrhea (yes vs. no)1.360.160.940.821.200.60
Rash (yes vs. no)1.010.940.830.311.100.71
rs689 (INS)Yes vs. no0.47*<0.00011.06*0.680.560.01
rs231775 (CTLA4)Yes vs. no0.88*0.381.33*
rs2476601 (PTPN22)Yes vs. no1.77<0.00011.630.0021.700.02
rs2816316 (RGS1)Yes vs. no0.970.830.990.921.400.12
rs10517086Yes vs. no1.050.700.980.881.310.21
rs4948088 (COBL)Yes vs. no0.560.050.860.560.610.29
rs2292239 (ERBB3)Yes vs. no1.420.011.600.0021.300.23
rs3184504 (SH2B3)Yes vs. no1.250.151.760.0011.120.64
rs12708716 (CLEC16A)Yes vs. no0.960.780.760.060.670.06
rs3757247 (BACH2)Yes vs. no0.78*0.071.49*
  • Data set in boldface indicate statistical significance. Lower resp., lower-respiratory infection; Upper resp., upper-respiratory infection.

  • *IAA only–to–GADA only ratio significantly changed (P < 0.05) by factor as determined in multivariate logistic regression.