Table 3

Risk factors associated with cardiovascular death

Risk factorAdjusted HR (95% CI)P value
Age per 5-year increase1.19 (1.12–1.26)< 0.0001
Prior MI1.44 (1.20–1.73)0.0001
Asymptomatic (no CHF) vs. NYHA I0.53 (0.37–0.76)0.0005
NYHA II vs. NYHA I1.15 (0.77–1.73)0.49
NYHA III vs. NYHA I1.64 (1.02–2.63)0.0042
NYHA IV vs. NYHA I3.13 (0.94–10.4)0.064
History of PCI0.63 (0.51–0.76)< 0.0001
Female vs. male sex0.68 (0.55–0.83)0.0002
eGFR per log10 (mL/min/1.73 m2) higher0.48 (0.35–0.66)< 0.0001
Systolic BP ≤135 mmHg per 5-unit increase0.93 (0.88–0.97)0.0025
HbA1c (%) per 1% increase1.29 (1.08–1.54)0.0046
History of cerebrovascular disease1.29 (1.06–1.58)0.0109
BMI ≤30 kg/m2 per 5-unit increase0.70 (0.59–0.83)0.0001
  • By Cox proportional hazards model, multivariable analysis. Other variables in the model were Latin America vs. North America (HR 1.83 [95% CI 1.3–2.6]; P = 0.0006); Asia Pacific/other vs. North America (HR 1.40 [95% CI 1.04–1.89]; P = 0.28); Western Europe vs. North America (HR 1.05 [95% CI 0.73–1.50]; P = 0.79); Eastern Europe vs. North America (HR 1.50 [95% CI 1.11–2.03]; P = 0.008); BMI >30 kg/m2 (HR 1.13 [95% CI 1.00–1.29]; P = 0.049); and systolic BP >135 mmHg (HR 1.04 [95% CI 1.00–1.08]; P = 0.06). BP, blood pressure; CHF, congestive heart failure.