Table 8.3

Median monthly cost of maximum approved daily dose of noninsulin glucose-lowering agents in the U.S.

ClassCompound(s)Dosage strength/product (if applicable)Median AWP (min, max)Median NADAC (min, max)Maximum approved daily dose*
Biguanides• Metformin500 mg (IR)$84 ($4, $93)$22,000 mg
850 mg (IR)$108 ($6, $109)$32,550 mg
1,000 mg (IR)$87 ($4, $88)$22,000 mg
500 mg (ER)$89 ($82, $6,671)$5 ($5, $3,630)2,000 mg
750 mg (ER)$72 ($65, $92)$51,500 mg
1,000 mg (ER)$1,028 ($1,028, $7,214)$539 ($539, $5,189)2,000 mg
Sulfonylureas (2nd generation)• Glyburide5 mg$93 ($63, $103)$1720 mg
6 mg (micronized)$50 ($48, $71)$1212 mg (micronized)
• Glipizide10 mg (IR)$75 ($67, $97)$440 mg (IR)
10 mg (XL)$48$1620 mg (XL)
• Glimepiride4 mg$71 ($71, $198)$78 mg
Meglitinides (glinides)• Repaglinide2 mg$659 ($122, $673)$4016 mg
• Nateglinide120 mg$155$56360 mg
Thiazolidinediones• Pioglitazone45 mg$348 ($283, $349)$545 mg
• Rosiglitazone4 mg$387$3148 mg
α-Glucosidase inhibitors• Acarbose100 mg$104 ($104, $106)$25300 mg
• Miglitol100 mg$241N/A††300 mg
DPP-4 inhibitors• Sitagliptin100 mg$477$382100 mg
• Saxagliptin5 mg$462$3705 mg
• Linagliptin5 mg$457$3675 mg
• Alogliptin25 mg$449$35725 mg
Bile acid sequestrants• Colesevelam625 mg tabs$713$5703.75 g
1.875 g suspension$1,426$5723.75 g
Dopamine-2 agonists• Bromocriptine0.8 mg$784$6294.8 mg
SGLT2 inhibitors• Canagliflozin300 mg$512$411300 mg
• Dapagliflozin10 mg$517$41310 mg
• Empagliflozin25 mg$517$41525 mg
GLP-1 receptor agonists• Exenatide10 μg pen$802$64220 μg
• Lixisenatide20 μg pen$669N/A††20 μg
• Liraglutide18 mg/3 mL pen$968$7751.8 mg
• Exenatide (extended release)2 mg powder for suspension or pen$747$6002 mg**
• Albiglutide50 mg pen$626$50050 mg**
• Dulaglutide1.5/0.5 mL pen$811$6481.5 mg**
Amylin mimetics• Pramlintide120 μg pen$2,336N/A††120 μg/injection†††
  • ER and XL, extended release; IR, immediate release.

  • †Calculated for 30-day supply (AWP or NADAC unit price × number of doses required to provide maximum approved daily dose × 30 days); median AWP or NADAC listed alone when only one product and/or price.

  • *Utilized to calculate median AWP and NADAC (min, max); generic prices used, if available commercially.

  • †† Not applicable; data not available.

  • ** Administered once weekly.

  • ††† AWP and NADAC calculated based on 120 μg three times daily.