Table 1

Baseline characteristics of ARIC participants with diagnosed diabetes at visit 4 (1996–1998) by severe hypoglycemia (n = 1,209)

No severe hypoglycemia (n = 1,014)Severe hypoglycemia (n = 195)*P value
Age, years63.4 ± 5.764.7 ± 5.60.004
Female53.757.90.28
Black31.246.7<0.001
BMI, kg/m231.4 ± 5.932.4 ± 5.80.028
Diabetes medications<0.001
 None30.28.2
 Oral medication(s) only45.441.5
 Any insulin24.550.3
Fructosamine<0.001
 Middle tertile (296–351 μmol/L)33.232.3
 Highest tertile (≥352 μmol/L)29.451.8
Diabetes duration ≥9 years40.460.0<0.001
eGFR <60 mL/min/1.73 m210.719.00.001
Albuminuria<0.001
 ACR 30 to <300 mg/g13.820.0
 ACR ≥300 mg/g6.614.9
Household income<0.001
 <$12,00016.932.3
 $12,000–23,99927.026.7
 $24,000–49,99932.927.7
 ≥$50,00023.313.3
Disability23.937.9<0.001
Systolic blood pressure, mmHg131.6 ± 19.5135.6 ± 19.50.009
Hypertension medication68.376.40.03
LDL cholesterol, mg/dL116.6 ± 35.1122.2 ± 38.50.045
HDL cholesterol, mg/dL44.1 ± 13.746.4 ± 15.90.04
Cholesterol-lowering medication24.127.20.36
Smoking status0.19
 Current smoker12.714.9
 Former smoker48.141.0
History of coronary heart disease at visit 417.421.00.22
  • Data are presented as mean ± SD or percentage.

  • *Severe hypoglycemia occurred in 14 before visit 4, all others had hypoglycemia during follow-up.