Table 4

HR for the risk of pancreatic cancer associated with insulin prescriptions during follow-up

BelgiumLombardy RegionBelgium and Lombardy Region combined
Without insulin prescriptionWith insulin prescriptionWithout insulin prescriptionWith insulin prescriptionWithout insulin prescriptionWith insulin prescription
No pancreatic cancer (n)329,23638,533181,2418,341510,47746,874
Pancreatic cancer (n)367518461328828846
Cumulative incidence per 100,0001111,3442543,9321621,805
HR* (95% CI)1.006.61 (5.63–7.77)1.007.46 (6.00–9.35)1.006.89 (6.05–7.85)
  • *Use of insulin as time-dependent variable through Cox model stratified by age and sex.

  • †Summary HR calculated by fixed-effects meta-analysis.