Table 2

Relationships between adiposity and measured parameters of intrarenal hemodynamic function in adults with and without type 1 diabetes

VariablesControl subjects without diabetesPatients with type 1 diabetes
GFRINULINERPFPAHRVRGFRINULINERPFPAHRVR
WB adiposity
 WB fat mass (per kg)
  r−0.12, P = 0.33−0.09, P = 0.450.12, P = 0.330.42, P = 0.00040.31, P = 0.010.28, P = 0.02
  β ± SE*−0.17 ± 0.24, P = 0.491.01 ± 1.52, P = 0.520.42 ± 0.45, P = 0.351.07 ± 0.25, P < 0.00013.18 ± 1.46, P = 0.030.97 ± 0.48, P = 0.046
  β ± SE−0.17 ± 0.25, P = 0.491.00 ± 1.61, P = 0.540.34 ± 0.46, P = 0.461.08 ± 0.25, P < 0.00013.28 ± 1.46, P = 0.030.94 ± 0.48, P = 0.054
 WB fat percentage (per %)
  r−0.18, P = 0.13−0.06, P = 0.600.26, P = 0.030.35, P = 0.0040.34, P = 0.0060.29, P = 0.02
  β ± SE*−0.46 ± 0.39, P = 0.260.05 ± 2.58, P = 0.990.93 ± 0.73, P = 0.191.43 ± 0.31, P < 0.00014.32 ± 1.81, P = 0.021.13 ± 0.60, P = 0.06
  β ± SE−0.49 ± 0.42, P = 0.25−0.10 ± 2.72, P = 0.970.86 ± 0.77, P = 0.271.43 ± 0.31, P < 0.00014.33 ± 1.45, P = 0.021.12 ± 0.60, P = 0.06
 BMI (per kg/m2)
  r−0.06, P = 0.640.23, P = 0.046−0.02, P = 0.880.32, P = 0.009−0.18, P = 0.160.13, P = 0.29
  β ± SE*0.25 ± 0.42, P = 0.564.58 ± 2.64, P = 0.070.10 ± 0.78, P = 0.901.44 ± 0.48, P = 0.004−4.49 ± 2.61, P = 0.091.20 ± 0.86, P = 0.17
  β ± SE0.28 ± 0.44, P = 0.535.12 ± 2.77, P = 0.07−0.13 ± 0.81, P = 0.871.46 ± 0.49, P = 0.004−4.96 ± 2.64, P = 0.071.08 ± 0.88, P = 0.22
Central body adiposity
 Trunk fat mass (per kg)
  r−0.13, P = 0.27−0.08, P = 0.510.11, P = 0.350.46, P < 0.00010.31, P = 0.010.28, P = 0.02
  β ± SE*−0.40 ± 0.42, P = 0.351.10 ± 2.66, P = 0.690.90 ± 0.78, P = 0.251.88 ± 0.42, P < 0.00015.56 ± 2.48, P = 0.031.68 ± 0.81, P = 0.04
  β ± SE−0.42 ± 0.44, P = 0.351.04 ± 2.87, P = 0.720.78 ± 0.82, P = 0.341.89 ± 0.43, P < 0.00015.77 ± 2.48, P = 0.021.62 ± 0.82, P = 0.052
 Trunk fat percentage (per %)
  r−0.20, P = 0.10−0.07, P = 0.580.25, P = 0.030.42, P = 0.00050.36, P = 0.0030.31, P = 0.01
  β ± SE*−0.44 ± 0.33, P = 0.18−0.82 ± 2.12, P = 0.701.00 ± 0.60, P = 0.101.18 ± 0.25, P < 0.00013.78 ± 1.46, P = 0.011.02 ± 0.49, P = 0.04
  β ± SE−0.48 ± 0.35, P = 0.17−1.07 ± 2.26, P = 0.640.93 ± 0.64, P = 0.151.18 ± 0.25, P < 0.00013.85 ± 1.46, P = 0.011.00 ± 0.49, P = 0.04
WB lean mass (per kg)
  r0.11, P = 0.360.22, P = 0.0590.25, P = 0.04−0.07, P = 0.550.06, P = 0.65−0.05, P = 0.69
  β ± SE*0.05 ± 0.04, P = 0.903.04 ± 2.63, P = 0.250.22 ± 0.76, P = 0.77−0.31 ± 0.33, P = 0.36−1.81 ± 1.77, P = 0.310.56 ± 0.58, P = 0.33
  β ± SE0.06 ± 0.04, P = 0.903.02 ± 2.66, P = 0.260.16 ± 0.77, P = 0.83−0.31 ± 0.34, P = 0.37−1.88 ± 0.77, P = 0.290.53 ± 0.58, P = 0.36
  • Data are expressed as the mean ± SD, unless otherwise indicated. Boldface type indicates statistical significance (P < 0.05). WB, whole body.

  • *β ± SE adjusted for age, sex, and HbA1c.

  • †β ± SE adjusted for age, sex, HbA1c, and SBP.