Table 3

Relationships between adiposity and measured parameters of intrarenal hemodynamic function in adults with type 1 diabetes with and without DN

VariablesDN ResistorsAdults with DN
GFRINULINERPFPAHRVRGFRINULINERPFPAHRVR
WB adiposity
 WB fat mass (per kg)
  r0.41, P = 0.0070.46, P = 0.0020.45, P = 0.003−0.35, P = 0.110.28, P = 0.20−0.22, P = 0.33
  β ± SE*0.98 ± 0.34, P = 0.0074.46 ± 2.03, P = 0.031.53 ± 0.64, P = 0.021.04 ± 0.44, P = 0.031.31 ± 2.10, P = 0.54−0.03 ± 0.80, P = 0.97
  β ± SE0.99 ± 0.35, P = 0.0074.50 ± 2.04, P = 0.031.51 ± 0.64, P = 0.020.98 ± 0.45, P = 0.0461.12 ± 2.18, P = 0.61−0.01 ± 0.83, P = 0.89
 WB fat percentage (per %)
  r−0.28, P = 0.070.39, P = 0.0090.33, P = 0.03−0.33, P = 0.130.12, P = 0.60−0.06, P = 0.81
  β ± SE*1.28 ± 0.40, P = 0.0035.40 ± 2.37, P = 0.031.65 ± 0.77, P = 0.041.42 ± 0.52, P = 0.020.40 ± 2.64, P = 0.88−0.11 ± 1.00, P = 0.91
  β ± SE1.28 ± 0.40, P = 0.0035.44 ± 2.39, P = 0.031.63 ± 0.77, P = 0.041.40 ± 0.52, P = 0.020.34 ± 2.70, P = 0.90−0.13 ± 1.02. P = 0.90
 BMI (per kg/m2)
  r−0.29, P = 0.0530.35, P = 0.020.35, P = 0.02−0.36, P = 0.100.24, P = 0.29−0.28, P = 0.20
  β ± SE*−0.97 ± 0.68, P = 0.16−5.61 ± 3.80, P = 0.151.84 ± 1.22, P = 0.141.96 ± 0.77, P = 0.020.57 ± 3.82, P = 0.88−0.38 ± 1.44, P = 0.79
  β ± SE−1.02 ± 0.69, P = 0.15−5.92 ± 3.85, P = 0.131.70 ± 1.23, P = 0.171.85 ± 0.82, P = 0.04−0.00 ± 4.04, P = 0.990.17 ± 1.53, P = 0.91
Central body adiposity
 Trunk fat mass (per kg)
  r0.44, P = 0.0040.53, P = 0.00020.53, P = 0.00030.43, P = 0.0470.33, P = 0.14−0.27, P = 0.22
  β ± SE*1.84 ± 0.64, P = 0.00610.34 ± 3.62, P = 0.0073.54 ± 1.14, P = 0.0041.69 ± 0.66, P = 0.023.28 ± 3.19, P = 0.32−0.54 ± 1.23, P = 0.66
  β ± SE1.86 ± 0.64, P = 0.00610.47 ± 3.65, P = 0.0073.48 ± 1.14, P = 0.0041.60 ± 0.69, P = 0.033.04 ± 3.32, P = 0.37−0.70 ± 1.28, P = 0.59
 Trunk fat percentage (per %)
  r0.32, P = 0.030.47, P = 0.0010.41, P = 0.0060.50, P = 0.020.16, P = 0.48−0.11, P = 0.63
  β ± SE*1.05 ± 0.33, P = 0.0045.85 ± 1.93, P = 0.0041.83 ± 0.62, P = 0.0061.22 ± 0.38, P = 0.0050.98 ± 2.01, P = 0.63−0.27 ± 0.76, P = 0.72
  β ± SE1.06 ± 0.34, P = 0.0045.94 ± 1.95, P = 0.0041.79 ± 0.62, P = 0.0071.19 ± 0.38, P = 0.0070.89 ± 2.06, P = 0.67−0.32 ± 0.78, P = 0.69
WB lean mass (per kg)
  r−0.17, P = 0.29−0.04, P = 0.820.08, P = 0.63−0.07, P = 0.750.13, P = 0.57−0.18, P = 0.43
  β ± SE*−0.22 ± 0.38, P = 0.57−2.06 ± 2.13, P = 0.340.52 ± 0.69, P = 0.46−0.11 ± 0.88, P = 0.902.53 ± 3.66, P = 0.500.84 ± 1.39, P = 0.55
  β ± SE−0.21 ± 0.39, P = 0.59−1.98 ± 2.17, P = 0.370.60 ± 0.69, P = 0.39−0.39 ± 1.00, P = 0.701.96 ± 4.29, P = 0.650.58 ± 1.62, P = 0.73
  • Boldface type indicates statistical significance (P < 0.05). WB, whole body.

  • *β ± SE adjusted for age, sex, and HbA1c.

  • †β ± SE adjusted for age, sex, HbA1c, and SBP.