Table 2

Subject characteristics and islet morphometric analyses in individuals with CF, subdivided according to diabetes and lung transplant status

CF-no DMCFRD
No lung transplantLung transplantNo lung transplantLung transplant
N134610
Age (years)11.9 ± 2.420.3 ± 1.022.8 ± 3.431.4 ± 2.8
Sex (female/male)11/21/33/36/4
BMI (kg/m2)15.2 ± 0.620.3 ± 2.821.9 ± 1.322.0 ± 1.2
Diabetes duration (years)6.6 ± 3.14.2 ± 1.0
HbA1c (%) (n = 4–6)7.8 ± 0.96.5 ± 0.4
Subjects with islet IL-1β, n (%)11 (91)2 (50)6 (100)8 (80)
IL-1β–positive islets (%)28.8 ± 8.531.1 ± 18.863.5 ± 9.561.8 ± 12.3
Subjects with islet amyloid, n (%)2 (11)1 (25)3 (50)7 (70)
Amyloid-positive islets (%)3.3 ± 3.20.3 ± 0.35.2 ± 3.231.0 ± 12.2
Insulin-positive area (%)1.5 ± 0.32.8 ± 0.91.1 ± 0.41.3 ± 0.2
Glucagon-positive area (%)1.2 ± 0.33.5 ± 0.61.5 ± 0.52.5 ± 0.7
Somatostatin-positive area (%) (n = 8, 3, 4, and 5, respectively)0.5 ± 0.10.6 ± 0.20.2 ± 0.10.7 ± 0.3
PP-positive area (%) (n = 8, 3, 4, and 5, respectively)0.6 ± 0.10.1 ± 0.1*0.2 ± 0.10.2 ± 0.1
  • Data are mean ± SEM or n unless otherwise indicated.

  • *P < 0.05 vs. CF-no DM, no transplant group.