Table 2

Clinical characteristics of FinnDiane patients stratified by the presence of CKD and PDR

+CKD/−PDR−CKD/−PDR+CKD/+PDR−CKD/+PDR
N21228170256
Sex (male)57.148.362.955.1
Age (years)48.4 (40.2, 53.0)45.2 (39.4, 51.1)44.0 (39.2, 49.7)45.6 (38.3, 50.7)
Age at diagnosis (years)12.1 (7.5, 18.3)*12.1 (6.9, 17.5)10.4 (6.1, 15.4)9.5 (5.5, 14.2)
Duration (years)33.9 (27.3, 36.2)31.5 (28.3, 36.2)32.9 (28.9, 36.9)33.2 (28.6, 39.3)
Daily insulin dose (units/kg)0.5 (0.43, 0.78)0.61 (0.51, 0.73)0.67 (0.53, 0.84)0.63 (0.52, 0.77)
HbA1c (%)7.8 (7.3, 8.6)*8.0 (7.4, 8.7)8.4 (7.5, 9.2)8.4 (7.8, 9.3)
HbA1c (mmol/mol)62 (56, 71)*64 (57, 72)68 (58, 77)68 (62, 78)
Total cholesterol (mmol/L)5.2 (4.5, 5.8)*5.0 (4.4, 5.6)5.3 (4.7, 6.2)5.0 (4.4, 5.7)
LDL cholesterol (mmol/L)3.3 (3.0, 4.3)3.2 (2.6, 3.7)3.4 (2.8, 4.1)3.2 (2.7, 3.8)
HDL cholesterol (mmol/L)1.0 (0.9, 1.5)*1.3 (1.1, 1.6)1.1 (0.9, 1.4)1.3 (1.1, 1.4)
Triglycerides (mmol/L)1.32 (1.14, 1.67)*0.93 (0.72, 1.36)1.59 (1.16, 2.39)1.09 (0.85, 1.48)
BMI (kg/m2)24.2 (22.0, 25.9)*24.6 (22.7, 27.3)24.7 (22.3, 27.5)25.6 (23.3, 28.2)
eGFR (mL/min/1.73 m2)40.8 (21.7, 44.1)*86.9 (75.4, 100.2)33.3 (16.2, 43.7)77.6 (63.0, 94.2)
Serum creatinine (µmol/L)151.0 (123.3, 231.2)*79.3 (70.2, 91.7)188.2 (120.4, 332.5)88.9 (79.3, 104.2)
ACR (mg/mmol)3.0 (0.3, 9.8)*0.1 (0.1, 0.4)3.3 (0.5, 13.5)0.6 (0.1, 3.0)
CRP (mg/L)3.3 (2.2, 5.7)*2.0 (1.2, 4.2)2.5 (1.6, 6.2)2.3 (1.4, 4.4)
Systolic blood pressure (mmHg)149 (137, 165)*134 (126, 145)151 (137, 168)141 (128, 153)
Diastolic blood pressure (mmHg)83 (78, 88)*80 (72, 86)85 (78, 90)80 (72, 88)
Detectable C-peptide levels23.510.013.910.6
CVD19.1*6.637.115.1
Antihypertensive medication95.2*40.896.573.4
Lipid-lowering medication38.1*12.738.220.3
Exercise66.769.857.762.1
Smoking14.327.419.422.8
  • Data are median (IQR) or %. Exercise data available in 50% of the patients. Boldface text highlights the differences between groups (equals *P < 0.05 between all groups).