Table 1

Insulin delivery characteristics and time in range at baseline, week 1, month 1, month 2, and month 3 of the trial period

PeriodMean ± SDP value change from baseline
Mean TDD of insulin (units/day)Baseline58.6 ± 19.1N/A
Days 1–758.2 ± 20.10.83
Days 22–2860.6 ± 21.50.41
Days 50–5658.9 ± 22.30.91
Days 78–8460.3 ± 21.50.49
Mean basal/auto-basal insulin dose (units/day)Baseline25.8 ± 8.3N/A
Days 1–727.1 ± 10.60.22
Days 22–2827.0 ± 9.60.31
Days 50–5626.0 ± 9.10.86
Days 78–8426.7 ± 9.30.37
Mean bolus insulin (units/day)Baseline32.6 ± 13.7N/A
Days 1–731.1 ± 12.90.27
Days 22–2833.8 ± 14.40.44
Days 50–5632.9 ± 15.80.86
Days 78–8433.5 ± 15.10.59
Percentage basal/bolus splitBaseline45.1 ± 9.2N/A
Days 1–746.9 ± 10.30.25
Days 22–2844.9 ± 9.00.87
Days 50–5645.1 ± 10.80.99
Days 78–8444.8 ± 10.30.82
Mean 24-h basal program for OL (units/day)Baseline26.7 ± 8.8N/A
Days 1–726.8 ± 8.70.10
Days 22–2826.6 ± 8.70.74
Days 50–5626.9 ± 8.90.21
Days 78–8427.0 ± 9.10.18
C-to-I ratio
 8 a.m.Baseline7.9 ± 2.7N/A
Days 1–77.4 ± 2.50.017
Days 22–287.0 ± 2.70.0014
Days 50–566.9 ± 2.7<0.0001
Days 78–846.8 ± 2.80.0002
 12 p.m.Baseline8.9 ± 3.3N/A
Days 1–78.4 ± 3.10.0085
Days 22–287.8 ± 2.9<0.0001
Days 50–567.6 ± 3.0<0.0001
Days 78–847.6 ± 3.1<0.0001
 6 p.m.Baseline8.7 ± 3.4N/A
Days 1–78.1 ± 3.10.0004
Days 22–287.4 ± 2.7<0.0001
Days 50–567.3 ± 2.7<0.0001
Days 78–847.2 ± 2.6<0.0001
Insulin action time (min)Baseline174.2 ± 51.6N/A
Days 1–7171.6 ± 49.20.16
Days 22–28168.4 ± 46.90.083
Days 50–56169.2 ± 47.30.15
Days 78–84168.4 ± 46.90.083
Percentage time in range 70–180 mg/dL
 OverallBaseline55.3 ± 14.9N/A
Days 1–768.4 ± 11.5<0.0001
Days 22–2867.4 ± 10.1<0.0001
Days 50–5670.2 ± 8.9<0.0001
Days 78–8469.0 ± 12.0<0.0001
 HCL ModeBaselineN/AN/A
Days 1–769.7 ± 10.6N/A
Days 22–2869.5 ± 8.5N/A
Days 50–5671.9 ± 8.1N/A
Days 78–8471.5 ± 10.3N/A
 OLBaseline55.3 ± 14.9N/A
Days 1–756.6 ± 28.10.80
Days 22–2856.8 ± 25.90.75
Days 50–5660.3 ± 19.70.16
Days 78–8457.4 ± 28.80.67
  • N/A, not applicable.