Table 3

EuroQoL

MeasureVisitN = 48Mean (SD) or NNo Problems (%)Median (IQR) or NAny Problems (%)Effect sizeP value
VASBaseline4674.13 (14.66)75.00 (15.00)
Day 754779.06 (15.97)80.00 (20.00)0.29N.S.
Day 3654282.86 (14.46)85.00 (19.00)0.71<0.0001
Day 7303185.74 (15.36)91.00 (18.00)0.73<0.0001
Health Preference WeightBaseline470.87 (0.12)0.83 (0.22)
Day 75470.86 (0.15)0.84 (0.17)−0.06N.S.
Day 365410.86 (0.15)0.84 (0.17)−0.04N.S.
Day 730320.88 (0.18)1.00 (0.18)0.09N.S.
Usual ActivitiesBaseline4732 (68.09%)15 (31.91%)
Day 754735 (74.47%)12 (25.53%)N.S.
Day 3654233 (78.57%)9 (21.43%)N.S.
Day 7303227 (84.38%)5 (15.63%)0.0143
Anxiety/DepressionBaseline4732 (68.09%)15 (31.91%)
Day 754734 (72.34%)13 (27.66%)N.S.
Day 3654229 (69.05%)13 (30.95%)N.S.
Day 7303223 (71.88%)9 (28.13%)N.S.
MobilityBaseline4738 (80.85%)9 (19.15%)
Day 754740 (85.11%)7 (14.89%)N.S.
Day 3654134 (82.93%)7 (17.07%)N.S.
Day 7303226 (81.25%)6 (18.75%)N.S.
Pain/DiscomfortBaseline4725 (53.19%)22 (46.81%)
Day 754727 (57.45%)20 (42.55%)N.S.
Day 3654224 (57.14%)18 (42.86%)N.S.
Day 7303222 (68.75%)10 (31.25%)N.S.
Self-CareBaseline4745 (95.74%)2 (4.26%)
Day 754746 (97.87%)1 (2.13%)N.S.
Day 3654239 (92.86%)3 (7.14%)N.S.
Day 7303229 (90.63%)3 (9.38%)N.S.
  • The EQ-5D VAS, Health Preference Weight, and five dimensions stratified by post–initial transplantation study visits. Effect sizes were calculated as the mean individual change from baseline divided by the baseline SD; a value of 0.5 (i.e., half an SD) was determined to be the MID. No effect size calculations were made for the five categorical dimensions. The five EQ-5D dimensions comprise three-level ordinal categorical responses. These responses were dichotomized as either “No Problems” or “Any Problems” based on a scoring option referenced in the EQ-5D user guide (29). Larger EQ-5D VAS and Health Preference Weight values indicate better health utility. Tests for change from baseline were performed using the Wilcoxon signed rank test for continuous outcomes and the McNemar test for categorical outcomes. IQR, interquartile range; N.S., not significant.