Table 3

Risk of incident DPN by clinically relevant changes in continuous potential risk factors for incident DPN and by doubling of methylglyoxal present at the diagnosis of type 2 diabetes found by screening: ADDITION-Denmark

HR of incident DPN (95% CI)
HbA1c (unit = 1%)0.93 (0.75; 1.15)
HbA1c (unit = 10 mmol/mol)0.94 (0.77; 1.14)
SBP (unit = 10 mmHg)1.02 (0.90; 1.16)
DBP (unit = 5 mmHg)0.96 (0.83; 1.12)
Height (unit = 5 cm)0.97 (0.83; 1.13)
Weight (unit = 5 kg)1.09 (1.03; 1.16)*
Waist circumference (unit = 5 cm)1.14 (1.05; 1.24)*
BMI (unit = 2 kg/m2)1.14 (1.06; 1.23)*
Total cholesterol (unit = 0.5 mmol/L)0.90 (0.80; 1.01)
LDL cholesterol (unit = 0.25 mmol/L)0.92 (0.86; 0.98)*
HDL cholesterol (unit = 0.25 mmol/L)0.82 (0.69; 0.99)*
Triglycerides (unit = 0.5 mmol/L)1.04 (0.98; 1.09)
Log2 methylglyoxal (unit = doubling)1.45 (1.12; 1.89)*
  • The risk of incident DPN is expressed by HR (95% CI) from Cox proportional hazard models adjusted for trial randomization group, sex, and age.

  • *P value <0.05.

  • †The HRs can be converted from HR per x units (e.g., per 10 mmHg in SBP) to HR per y units (e.g., per 1 mmHg in SBP) using the following equation: HR(y/x). For example, the HR for SBP per 1 mmHg is (1.02)1/10 = 1.00. The same equation applies to the CI. The χ2 test and P values are unchanged by a change of scale.