Table 1

Baseline characteristics of participants by incident DPN status during 13 years of follow-up: ADDITION-Denmark

CharacteristicsParticipants without incident DPNParticipants with incident DPNN
Number (%) of participants1,178 (81.5)78 (5.4)1,256
Intensive randomization group686 (58.2)44 (56.4)1,256
Male sex693 (58.8)42 (53.8)1,256
Age (years)60.9 (55.6; 65.7)60.6 (56.5; 63.9)1,209
HbA1c (%)6.3 (6.0; 6.9)6.4 (6.0; 6.9)1,214
HbA1c (mmol/mol)45 (42; 52)46 (42; 52)1,214
SBP (mmHg)148.0 (135.2; 162.3)*150.5 (134.0; 167.0)*1,206
DBP (mmHg)87.3 (80.7; 94.7)*86.5 (77.0; 97.3)*1,206
Height (cm)170.6 (163.5; 176.9)168.6 (163.9; 176.8)1,206
Weight (kg)87.4 (77.2; 98.8)*90.5 (83.3; 101.7)*1,206
Waist circumference (cm)103.5 (95.0; 112.5)*106.3 (101.5; 112.0)*1,203
BMI (kg/m2)30.0 (27.0; 33.0)*32.0 (28.0; 34.0)*1,206
Total cholesterol (mmol/L)5.6 (4.9; 6.4)*5.5 (4.8; 6.2)*1,158
LDL cholesterol (mmol/L)3.4 (2.8; 4.0)*3.1 (2.5; 3.9)*1,098
HDL cholesterol (mmol/L)1.3 (1.2; 1.6)1.3 (1.0; 1.6)1,133
Triglycerides (mmol/L)1.6 (1.1; 2.2)1.7 (1.3; 2.6)1,147
Methylglyoxal (nmol/L)254 (175; 406)272 (177; 404)1,065
Smoking
 Nonsmoker320 (27.5)27 (35.1)1,242
 Former smoker404 (34.7)19 (24.7)1,242
 Current smoker441 (37.9)31 (40.3)1,242
Alcohol330 (31.0)19 (27.5)1,134
Treatment with statins145 (12.4)8 (10.3)1,252
Treatment with antihypertensives494 (42.1)37 (47.4)1,252
Treatment with aspirin 141 (12.0)11 (14.1)1,252
History of CVD67 (5.7)8 (10.3)1,256
  • Categorical data are n (%), and continuous data are median (IQR). N, number of observations.

  • *P < 0.05.

  • †Weekly alcohol consumption exceeding recommended intake (>7 units in women and >14 units in men).

  • ‡History of CVD: nonfatal myocardial infarction or stroke up to 10 years prior to the diagnosis of type 2 diabetes.