Table 3

Regression model of severe hypoglycemia events to identify important patient characteristics associated with severe hypoglycemia

VariablesOR (95% CI)P
Intercept0.001 (0, 0.004)<0.001
Insulin2.773 (1.975, 3.892)<0.001
Sulfonylureas2.487 (1.919, 3.223)<0.001
AGI2.049 (0.699, 6.009)0.19
DPP-4 inhibitor0.514 (0.354, 0.744)0.001
GLP-1 agonist0.225 (0.081, 0.623)0.004
Metformin0.431 (0.321, 0.578)<0.001
Meglitinide1.181 (0.492, 2.833)0.71
SGLT2 inhibitor0.001 (0, 1.8e+14)0.71
TZD0.725 (0.433, 1.215)0.22
Number of diabetes medications1.558 (1.357, 1.789)<0.001
History of nonsevere hypoglycemia diagnosis3.01 (2.087, 4.343)<0.001
Age1.009 (0.998, 1.02)0.10
BMI0.962 (0.945, 0.98)<0.001
HbA1c <6% (42 mmol/mol)1.952 (1.436, 2.652)<0.001
Median income1.002 (0.997, 1.006)0.41
Male sex 0.672 (0.532, 0.849)0.001
Race
 CaucasianReference
 Black 2.553 (1.962, 3.322)<0.001
 Asian/Pacific Islander1.221 (0.38, 3.928)0.73
 Other0.798 (0.389, 1.638)0.54
Dementia0.773 (0.487, 1.226)0.27
Cognitive impairment1.398 (0.949, 2.057)0.09
Cardiovascular disease1.684 (1.242, 2.283)0.001
Congestive heart failure1.331 (1.013, 1.75)0.04
Chronic kidney disease1.266 (0.949, 1.688)0.11
Depression1.081 (0.815, 1.434)0.59
Other psychiatric diagnoses0.924 (0.712, 1.199)0.55
Alcohol or substance abuse1.045 (0.765, 1.428)0.78
Charlson comorbidity index1.153 (1.096, 1.212)<0.001