Table 1

Participant characteristics

CONNAFL−NAFL+NASH
N (females)7 (5)7 (6)7 (4)7 (6)
Age (years)40 ± 1343 ± 746 ± 1242 ± 8
BMI (kg/m2)25.2 ± 3.3¶¶¶,###,***49.5 ± 8.356.1 ± 7.051.4 ± 7.1
Waist circumference (cm)82.8 ± 13.0¶¶,###,**125.7 ± 19.8144.5 ± 16.2129.2 ± 17.0
Triglycerides (mg/dL)75 (71, 94)138 (74, 166)135 (94, 286)99.5 (94, 120)
FFA (μmol/L)635 (473, 761)819 (634, 947)509 (261, 730)599 (577, 671)
HDL-cholesterol (mg/dL)64 (57, 83),#44 (35, 54)35 (33,45)52 (43, 59)
LDL-cholesterol (mg/dL)89 (72, 99),#128 (105, 153)128 (100, 151)118 (107, 118)
Alanine aminotransferase (units/L)25 (19, 34)25 (14, 25)22 (17, 25)32 (28, 40)
Aspartate aminotransferase (units/L)19 (19, 20)20 (17, 23)25 (19, 27)25.5 (18, 31)
γ-Glutamyltransferase (units/L)24 (16, 35)16 (10, 35)22 (15, 35)32 (28, 40)
NAFLD activity score0 (0, 2)##,***0 (0, 1)‡‡,§§§2 (2, 4)††5 (4, 6)
Peripheral insulin sensitivity (mg/kg/min)7.4 ± 2.2¶¶,##3.1 ± 1.71.8 ± 0.32.8 ± 0.6
HIS index ([mg/kg/min]/[μU/mL])15.1 ± 14.04.8 ± 2.11.7 ± 0.14.8 ± 4.4
Hepatocellular lipids (%)1 (0, 5)##,***2 (0, 5)‡‡,§§§40 (10, 40)45 (40, 65)
  • Data are presented as mean ± SD or median (quartile 1, quartile 3) unless otherwise indicated

  • **P ≤ 0.01, ***P < 0.001 CON vs. NASH.

  • P ≤ 0.05, ¶¶P ≤ 0.01, ¶¶¶P < 0.001 CON vs. NAFL−.

  • #P ≤ 0.05, ##P ≤ 0.01, ###P < 0.001 CON vs. NAFL+.

  • P ≤ 0.05, ‡‡P ≤ 0.01, NAFL− vs. NAFL+.

  • §§§P < 0.001 NAFL− vs. NASH.

  • P ≤ 0.05, ††P ≤ 0.01 NAFL+ vs. NASH.