Table 2

Baseline characteristics and changes in parameters after 20 weeks of treatment

Control group (n = 20)Empagliflozin group (n = 22)Difference between groups
BaselinePosttreatmentP valueBaselinePosttreatmentP valueP value
Demographic
 Weight (kg)81.1 (16.1)79.5 (14.9)0.02280.8 (13.0)77.5 (11.0)0.0010.154
 BMI (kg/m2)29.4 (3.1)28.8 (2.8)0.01930.0 (3.8)28.7 (3.5)0.0010.124
 Seated SBP (mm/Hg)130 (19)123 (13)0.099125 (13)124 (9)0.8350.253
 Seated DBP (mm/Hg)81 (12)81 (7)0.85579 (10)81 (5)0.4440.620
Biochemical profile
 Fasting glucose (mg/dL)176 (57)120 (19)<0.0001173 (44)124 (17)<0.0010.850
 HbA1c (%)9.1 (1.4)7.1 (0.9)<0.00019.0 (1.0)7.2 (0.6)<0.0010.880
 HbA1c (mmol/mol)76.1 (16.3)54.3 (9.8)<0.00175.1 (10.9)55.2 (5.9)<0.0010.601
 Serum creatinine (mg/dL)0.89 (0.25)0.91 (0.19)0.3190.81 (0.25)0.90 (0.24)0.0180.420
 Total bilirubin (mg/dL)0.7 (0.3)0.6 (0.2)0.4580.7 (0.3)0.6 (0.3)0.0410.256
 AST (units/L)45.3 (24.3)44.6 (23.8)0.93144.6 (23.5)36.2 (9.0)0.0400.212
 ALT (units/L)65.3 (40.3)61.6 (38.4)0.42264.3 (20.2)49.7 (25.8)0.0010.005
 GGT (units/L)63.9 (45.3)60.0 (39.0)0.42165.8 (36.1)50.9 (24.6)0.0020.057
 Albumin (units/L)4.26 (0.25)4.28 (0.35)0.8394.16 (0.35)4.30 (0.35)0.2310.411
 Triglycerides (mg/dL)212 (115)175 (43)0.019201 (124)155 (52)0.0100.678
 HDL (mg/dL)45 (15)47 (12)0.09742 (12)45 (12)0.0870.752
 LDL (mg/dL)114 (30)96 (17)0.001112 (35)95 (22)0.0180.512
  • Data are mean (SD). DBP, diastolic blood pressure; SBP, systolic blood pressure.