Table 2

Slopes (95% CIs) of the association of BMI with LDLc across participants with increasing count of MS criteria (other than WC) and across participants belonging to different age-groups in the nonobese and obese strata from the NHANES (U.S. population) and ENRICA (Spanish population) studies

BMI <30 kg/m2BMI ≥30 kg/m2
nSlope (95% CI) (mg/dL per kg/m2)P valuenSlope (95% CI) (mg/dL per kg/m2)P value
Count of MS criteria (other than WC)
 NHANES
  02,2782.41 (1.96, 2.86)Ref.481−1.00 (−1.93, −0.07)Ref.
  12,6011.41 (0.87, 1.94)0.008983−0.21 (−0.66, 0.24)0.141
  21,8342.15 (1.42, 2.87)0.5411,280−0.49 (−0.83, −0.15)0.344
  3776−0.73 (−1.86, 0.39)<0.001850−0.60 (−1.16, −0.03)0.448
  42960.54 (−1.73, 2.82)0.1073570.27 (−0.71, 1.25)0.070
 ENRICA
  03,5052.14 (1.74, 2.54)Ref.2600.73 (−0.74, 2.19)Ref.
  13,1951.78 (1.33, 2.24)0.238770−0.04 (−0.79, 0.71)0.362
  21,4981.22 (0.48, 1.96)0.031815−0.37 (−1.04, 0.30)0.186
  35780.03 (−1.55, 1.62)0.012509−0.34 (−1.27, 0.60)0.232
  4138−0.27 (−2.97, 2.43)0.0851840.06 (−1.20, 1.33)0.504
Age-group
 NHANES
  <40 years2,9292.39 (1.94, 2.83)<0.0011,324−0.62 (−0.99, −0.24)0.923
  40 to <60 years2,3831.61 (1.11, 2.12)0.0061,391−0.40 (−0.78, −0.01)0.612
  ≥60 years2,6720.49 (−0.06, 1.04)Ref.1,377−0.58 (−1.19, 0.03)Ref.
 ENRICA
  <40 years3,3482.14 (1.76, 2.52)<0.001465−0.21 (−1.08, 0.65)0.781
  40 to <60 years3,5301.76 (1.29, 2.23)<0.0011,061−0.46 (−1.04, 0.13)0.360
  ≥60 years2,177−0.29 (−0.82, 0.25)Ref.1,057−0.07 (−0.67, 0.54)Ref.
  • The slopes are derived from generalized linear models of the interaction between BMI and the number of MS criteria and interaction between BMI and age-group. Models were correspondingly adjusted for age and sex or only for sex, and they were created separately for each obesity stratum. Differences between the slopes of the groups with the reference (Ref., zero criteria or elder group, respectively) were tested by observing the interaction term P value. Multiply by 0.0259 to convert to mmol/L.