Table 3

Biochemical parameters before and after combined targeted immunosuppressive therapy

PretherapyPosttherapyP value
Median (25th, 75th IQR) Median (25th, 75th IQR)
Fasting glucose (mg/dL)307 (203, 397.8)79.5 (75.7, 92)<0.0001*
HbA1c (%)11.8 (9.7, 13.6)5.5 (5.2, 6)<0.0001*
Insulin dose (units/day)1,775 (863, 2,700)00.007*
Testosterone (ng/dL)
 Women 126 (57, 571)28 (20, 47)0.013*
 Men 635 (453.5, 789.5)499 (432, 566)0.04*
Triglycerides (mg/dL)58 (42, 73)55 (43, 81)0.87
Total cholesterol (mg/dL)129 (119, 145)152 (133, 156)0.28
LDL cholesterol (mg/dL)59.5 (46, 78)72 (56, 91)0.17
HDL cholesterol (mg/dL)58.5 (55, 73)60 (47, 79)0.66
  • There was normalization of fasting glycemia, significant reduction of HbA1c, reduction of daily insulin dosage to 0 units/day, and normalization of testosterone levels. There were no significant effects on lipids panel. Reference values for androgens in women: testosterone premenopausal women <81 ng/dL, postmenopausal women <63 ng/dL.

  • *Statistically significant (P < 0.05).