Table 3

Multivariable association of FG CV during young adulthood with cognitive function at examination year 30 (2015–2016)

Difference in year 30 cognitive test score per 1 SD CV-FG (95% CI)
Model 1*Model 2Model 3Model 3A§Model 3BModel 3C
DSST, n = 2,996−1.00 (−1.55, −0.45)−0.43 (−0.95, 0.10)−0.38 (−0.91, 0.15)−0.39 (−0.92, 0.14)−0.77 (−1.43, −0.10)−0.32 (−0.86, 0.22)
RAVLT, n = 3,011−0.16 (−0.27, −0.04)−0.07 (−0.18, 0.04)−0.07 (−0.19, 0.04)−0.07 (−0.19, 0.04)−0.10 (−0.24, 0.04)−0.06 (−0.18, 0.05)
Stroop Test, n = 2,9390.26 (−0.15, 0.67)−0.02 (−0.43, 0.38)−0.03 (−0.43, 0.38)−0.02 (−0.42, 0.39)0.07 (−0.44, 0.58)−0.03 (−0.45, 0.38)
MoCA, n = 2,994−0.23 (−0.36, −0.10)−0.11 (−0.23, 0.01)−0.10 (−0.22, 0.02)−0.11 (−0.23, 0.01)−0.21 (−0.36, −0.06)−0.11 (−0.23, 0.01)
Category fluency, n = 2,986−0.17 (−0.36, 0.02)−0.06 (−0.25, 0.13)−0.07 (−0.26, 0.12)−0.09 (−0.28, 0.10)−0.21 (−0.44, 0.03)−0.09 (−0.28, 0.10)
Letter fluency, n = 2,938−0.40 (−0.86, 0.06)−0.06 (−0.51, 0.39)−0.04 (−0.49, 0.41)−0.10 (−0.55, 0.35)−0.22 (−0.78, 0.35)−0.04 (−0.50, 0.42)
Global z score, n = 2,852−0.06 (−0.09, −0.02)−0.02 (−0.05, 0.01)−0.02 (−0.05, 0.01)−0.02 (−0.05, 0.01)−0.03 (−0.07, 0.004)−0.02 (−0.05, 0.01)
  • A 1-SD unit increment in CV-FG at year 30 is 3.3%.

  • *Model 1 adjustments: age, sex, race, field center.

  • †Model 2 adjustments: model 1 adjustments plus highest level of educational attainment and cumulative values for number of years as a current smoker, grams of alcohol consumed weekly, BMI, physical activity, systolic BP, use of BP-lowering medications, LDL-C, and use of cholesterol-lowering medications.

  • ‡Model 3 adjustments: model 2 adjustments plus weighted average of FG.

  • §Model 3A adjustments: model 3 adjustments plus the incidence of diabetes, diabetes medication use, and diabetes duration.

  • ‖Model 3B adjustments: model 3 adjustments plus change in FG level during variability measurement.

  • ¶Model 3C adjustments: model 3 adjustments plus year 30 FG level.