Table 2

Multivariable association of FG CV during young adulthood with cognitive function in middle age

Difference in year 25 cognitive test score per 1 SD CV-FG (95% CI)
Model 1*Model 2Model 3Model 3A§Model 3BModel 3C
DSST, n = 3,292−1.07 (−1.57, −0.58)−0.61 (−1.08, −0.14)−0.59 (−1.07, −0.12)−0.59 (−1.06, −0.11)−0.95 (−1.54, −0.36)−0.55 (−1.04, −0.07)
RAVLT, n = 3,287−0.16 (−0.26, −0.06)−0.09 (−0.19, 0.00)−0.11 (−0.21, −0.01)−0.11 (−0.21, −0.01)−0.14 (−0.27, −0.02)−0.11 (−0.21, −0.01)
Stroop Test, n = 3,2800.43 (0.08, 0.79)0.23 (−0.13, 0.58)0.21 (−0.14, 0.57)0.23 (−0.13, 0.58)0.49 (0.04, 0.94)0.26 (−0.10, 0.63)
Global z score, n = 3,254−0.07 (−0.10, −0.04)−0.04 (−0.07, −0.01)−0.04 (−0.07, −0.01)−0.04 (−0.07, −0.01)−0.06 (−0.09, −0.03)−0.04 (−0.07, −0.01)
  • A 1-SD unit increment in CV-FG at year 25 is 3.4%.

  • *Model 1 adjustments: age, sex, race, field center.

  • †Model 2 adjustments: model 1 adjustments plus highest level of educational attainment and cumulative values for number of years as a current smoker, grams of alcohol consumed weekly, BMI, physical activity, systolic BP, use of BP-lowering medications, LDL-C, and use of cholesterol-lowering medications.

  • ‡Model 3 adjustments: model 2 adjustments plus weighted average of FG.

  • §Model 3A adjustments: model 3 adjustments plus the incidence of diabetes, diabetes medication use, and diabetes duration.

  • ‖Model 3B adjustments: model 3 adjustments plus change in FG level during variability measurement.

  • ¶Model 3C adjustments: model 3 adjustments plus year 25 FG level.