Table 2

Multivariable analyses of time of conversion from confirmed single GAD65 or non-GAD65 autoantibody (i.e., either mIAA or IA-2 autoantibody) positivity to multiple autoantibody positivity

Time from confirmed single GAD65 autoantibody to multiple autoantibody positivity
FactorHR (95% CI)P value
TCF7L2 rs4506565_T variant (1 or 2 minor alleles vs. 0)0.65 (0.44–0.97)0.033
Age at single GAD65 autoantibody positivity0.99 (0.98–1.006)0.26
HLA DR3-DQ2 and/or DR4-DQ81.66 (1.02–2.7)0.04
Time from either mIAA or IA-2 autoantibody to multiple autoantibody positivity stratified by whether or not participants were overweight/obese*
FactorNot overweight/obese (n = 51, 25 events)Overweight/obese (n = 33, 22 events)
HR (95% CI)P valueHR (95% CI)P value
TCF7L2 rs4506565_T variant (1 or 2 minor alleles vs. 0)0.80 (0.36–1.79)0.593.02 (1.23–7.45)0.016
Age at single mIAA or IA-2 autoantibody positivity0.97 (0.93–1.01)0.140.97 (0.94–0.99)0.008
  • *HLA was removed from the model for being statistically nonsignificant.