Table 3

Association between baseline lipid scores and T2D risk

Quartiles of scoresLinear trendPer SD
Q1Q2Q3Q4
LP score (LPCs and LPEs); n molecules = 18
 M1*Ref0.82 (0.56–1.19)0.49 (0.32–0.75)0.46 (0.29–0.71)<0.0010.73 (0.63–0.85)
 M2*Ref0.86 (0.58–1.27)0.48 (0.31–0.76)0.51 (0.32–0.81)<0.0010.74 (0.63–0.87)
 M3*Ref1.09 (0.69–1.73)0.54 (0.30–0.97)0.66 (0.38–1.16)0.0400.79 (0.65–0.96)
PC-PL score; n molecules = 15
 M1*Ref0.78 (0.53–1.17)0.77 (0.52–1.16)0.36 (0.22–0.58)<0.0010.78 (0.68–0.90)
 M2*Ref0.80 (0.53–1.21)0.81 (0.54–1.22)0.38 (0.23–0.64)0.0010.82 (0.71–0.95)
 M3*Ref0.81 (0.49–1.33)0.66 (0.39–1.09)0.37 (0.20–0.68)0.0010.76 (0.62–0.92)
SM score; n molecules = 11
 M1*Ref0.49 (0.32–0.75)0.58 (0.38–0.89)0.32 (0.19–0.54)<0.0010.67 (0.56–0.80)
 M2*Ref0.46 (0.30–0.72)0.56 (0.35–0.87)0.31 (0.18–0.52)<0.0010.69 (0.57–0.83)
 M3*Ref0.30 (0.17–0.52)0.51 (0.30–0.88)0.24 (0.13–0.45)<0.0010.67 (0.54–0.84)
CE score; n molecules = 13
 M1*Ref0.76 (0.50–1.14)0.64 (0.43–0.95)0.34 (0.21–0.54)<0.0010.68 (0.58–0.79)
 M2*Ref0.87 (0.56–1.35)0.74 (0.49–1.12)0.39 (0.24–0.65)<0.0010.70 (0.59–0.84)
 M3*Ref0.64 (0.36–1.15)0.56 (0.34–0.91)0.40 (0.22–0.74)0.0020.68 (0.56–0.83)
TAG score (≤56 C and ≤3 double bonds); n molecules = 40
 M1*Ref1.73 (1.06–2.83)2.18 (1.35–3.51)2.94 (1.85–4.67)<0.0011.49 (1.27–1.75)
 M2*Ref1.77 (1.06–2.94)2.10 (1.28–3.43)2.55 (1.58–4.11)<0.0011.39 (1.18–1.64)
 M3*Ref1.60 (0.82–3.14)2.01 (1.04–3.86)2.02 (1.05–3.87)0.0441.23 (1.00–1.52)
DAG score; n molecules = 14
 M1*Ref1.14 (0.70–1.86)2.13 (1.35–3.36)2.76 (1.77–4.29)<0.0011.58 (1.33–1.86)
 M2*Ref1.25 (0.75–2.08)1.95 (1.21–3.14)2.46 (1.56–3.88)<0.0011.48 (1.24–1.77)
 M3*Ref1.18 (0.61–2.30)1.52 (0.84–2.74)1.93 (1.10–3.37)0.0081.31 (1.07–1.61)
PE score; n molecules = 12
 M1*Ref1.51 (0.95–2.39)1.57 (0.95–2.39)2.55 (1.64–3.95)<0.0011.45 (1.23–1.70)
 M2*Ref1.43 (0.89–2.31)1.48 (0.92–2.38)2.13 (1.35–3.35)0.0011.35 (1.15–1.59)
 M3*Ref1.30 (0.74–2.78)0.95 (0.52–2.42)1.39 (0.80–2.42)0.3211.13 (0.93–1.37)
  • Data are HR (95% CI) unless otherwise indicated. Boldface type indicates P values <0.05 for the association with T2D (HR).

  • *M1: adjusted for age, sex, and intervention group; M2: M1 additionally adjusted for BMI, smoking, hypertension, and dyslipidemia; M3: M2 additionally adjusted for baseline glucose (linear and quadratic term). Ref, reference; Q, quartile.