Table 2

HR and 95% CI of subjects with newly diagnosed type 2 diabetes by quartiles of FPG variability

Events (n)Follow-up duration (person-years)Incidence rate (per 1,000 person-years)UnadjustedModel 1Model 2
HR (95% CI)P valueHR (95% CI)P valueHR (95% CI)P value
FPG variability (FPG-CV)
 Q12,083264,2367.88111
 Q22,071263,9627.851.00 (0.94–1.06)0.91211.03 (0.97–1.10)0.30821.09 (1.03–1.16)0.0047
 Q32,303263,0398.761.11 (1.05–1.18)0.00041.14 (1.07–1.21)<0.00011.30 (1.22–1.38)<0.0001
 Q42,846259,68510.961.39 (1.32–1.47)<0.00011.37 (1.30–1.45)<0.00011.67 (1.58–1.77)<0.0001
P for trend<0.0001<0.0001<0.0001
FPG variability (FPG-SD)
 Q11,770265,6316.66111
 Q21,913264,6987.231.09 (1.02–1.16)0.01191.13 (1.06–1.20)0.00031.08 (1.01–1.15)0.0220
 Q32,367262,5349.021.36 (1.28–1.44)<0.00011.39 (1.30–1.47)<0.00011.29 (1.21–1.37)<0.0001
 Q43,253258,05812.611.90 (1.79–2.01)<0.00011.85 (1.75–1.97)<0.00011.63 (1.54–1.73)<0.0001
P for trend<0.0001<0.0001<0.0001
FPG variability (FPG-VIM)
 Q11,920264,9527.25111
 Q22,000264,2927.571.05 (0.98–1.11)0.16061.08 (1.02–1.15)0.01251.10 (1.03–1.17)0.0040
 Q32,332262,8178.871.23 (1.16–1.30)<0.00011.25 (1.18–1.33)<0.00011.28 (1.21–1.36)<0.0001
 Q43,051258,86011.791.63 (1.54–1.73)<0.00011.60 (1.51–1.69)<0.00011.65 (1.56–1.75)<0.0001
P for trend<0.0001<0.0001<0.0001
  • Model 1, adjusted for age and sex. Model 2, adjusted for age, sex, BMI, alcohol consumption, smoking, regular exercise, income, family history of diabetes, hypertension, dyslipidemia, and mean FPG. Q, quartile.