Table 2

Baseline parameters predictive of severe hypoglycemia (N = 1,791)

Univariate predictors of severe hypoglycemia
VariableNo severe hypoglycemic events (n = 1,523)At least one severe hypoglycemic event (n = 268)P value
Treatment group<0.001
 Standard (n = 899)810 (53.2)89 (33.2)
 Intensive (n = 892)713 (46.8)179 (66.8)
Age (years)60.2 ± 8.661.8 ± 8.80.005
Baseline insulin752 (49.4)186 (69.4)<0.001
History of hypoglycemia245 (16.1)59 (22.1)0.017
Neuropathy619 (40.7)142 (53.2)<0.001
Sex0.931
 Male1,479 (97.1)260 (97.0)
 Female44 (2.9)8 (3.0)
Time since diagnosis of T2DM (years)11.2 ± 7.413.0 ± 7.6<0.001
Previous CVD event599 (39.3)124 (46.3)0.033
Race/ethnicity0.849
 Non-Hispanic white939 (61.6)172 (64.2)
 Hispanic white250 (16.4)41 (15.3)
 Black258 (16.9)41 (15.3)
 Other76 (5.0)14 (5.2)
HDL (mg/dL)35.7 ± 9.937.2 ± 11.40.044
Creatinine (mg/dL)1.00 ± 0.211.05 ± 0.23<0.001
eGFR (mL/min/1.73 m2)83.1 ± 22.277.4 ± 20.0<0.001
UKPDS risk score0.36 ± 0.200.39 ± 0.210.010
Multivariate predictors of severe hypoglycemia
PredictorOdds ratio (95% CI)P value
 Intensive treatment arm2.20 (1.46, 3.29)<0.001
 Baseline BMI (per unit)0.95 (0.91, 0.99)0.017
 Proteinuria1.42 (1.09, 1.85)0.009
 Autonomic neuropathy1.75 (1.14, 2.69)0.010
 Insulin use at baseline1.68 (1.09, 2.60)0.020
  • Data are mean ± SD or n (%), unless otherwise indicated. Baseline values were measured upon entry into the original VADT.